Delfina Costa

TL;DR: This review will analyze the known functions of NK cells in the gut mucosa both in health and disease, focusing on the cross-talk among bowel microenvironment, epithelial barrier integrity, microbiota, and NK cells.

TL;DR: A bone loss during spaceflight in the weight-bearing bones of both strains was revealed, and osteocytes of the Wt mice, but not of Tg mice, acquired a round shape, thus showing for the first time osteocyte space-related morphological alterations in vivo.

TL;DR: It is found that LCN2 plays a role in bone development and turnover having both a negative effect on bone formation, by affecting growth plate development and interfering with osteoblast differentiation, and a positive effect onBone resorption by enhancing osteoclast compartment.

TL;DR: Aim of the present work was to verify whether inhibition of ADAM10 in HL cells could restore the triggering of NKG2D-dependent anti-lymphoma T cell response, and synthesized the two hydroxamate compounds LT4 and MN8 with selectivity forADAM10 over metalloproteases (MMPs), LT4 showing higher specificity for ADAM 10 over ADAM17.

TL;DR: It is shown that CRC, exposed to Zol, stimulates the expansion of Vδ2 T lymphocytes with effector memory phenotype and antitumor cytotoxic activity, besides sensitizing cancer cells to γδ T cell-mediated cytotoxicity.