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Aldo Profumo
Researcher at National Cancer Research Institute
Publications - 46
Citations - 716
Aldo Profumo is an academic researcher from National Cancer Research Institute. The author has contributed to research in topics: Cancer & Fibrinopeptide. The author has an hindex of 16, co-authored 42 publications receiving 588 citations. Previous affiliations of Aldo Profumo include Laboratory of Molecular Biology.
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Journal ArticleDOI
Fibrinogen species as resolved by HPLC-SAXS data processing within the UltraScan Solution Modeler (US-SOMO) enhanced SAS module
Emre H. Brookes,Javier Pérez,Barbara Cardinali,Aldo Profumo,Patrice Vachette,Patrice Vachette,Mattia Rocco +6 more
TL;DR: The usefulness of a new high-performance liquid chromatography/small-angle X-ray scattering (HPLC-SAXS) data analysis module within the multi-resolution modeling suite US-SOMO is illustrated with size-exclusion small-angle SXS data of a crude bovine serum albumin sample.
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Pharmacokinetics, pharmacodynamics and efficacy on pediatric tumors of the glioma radiosensitizer KU60019
Donatella Vecchio,Antonio Daga,Elisa Carra,Daniela Marubbi,Alessandro Raso,Samantha Mascelli,Paolo Nozza,Maria Luisa Garrè,Francesca Pitto,Jean Louis Ravetti,Stefano Vagge,Renzo Corvò,Aldo Profumo,Gabriella Baio,Diana Marcello,Guido Frosina +15 more
TL;DR: The results indicate that ATM inhibition may allow to radiosensitize a wide range of adult and pediatric high‐grade gliomas.
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Small molecules targeting histone demethylase genes (KDMs) inhibit growth of temozolomide-resistant glioblastoma cells.
Barbara Banelli,Antonio Daga,Alessandra Forlani,Giorgio Allemanni,Daniela Marubbi,Maria Pia Pistillo,Aldo Profumo,Massimo Romani +7 more
TL;DR: It is proposed that the combination between cytotoxic drugs and molecules acting on the epigenetic landscape may offer the opportunity to develop new therapies for this invariably lethal disease.
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Zoledronate can induce colorectal cancer microenvironment expressing BTN3A1 to stimulate effector γδ T cells with antitumor activity.
Maria Raffaella Zocchi,Delfina Costa,Roberta Venè,Francesca Tosetti,Nicoletta Ferrari,Simona Minghelli,Roberto Benelli,Stefano Scabini,Emanuele Romairone,Silvia Catellani,Aldo Profumo,Alessandro Poggi +11 more
TL;DR: It is shown that CRC, exposed to Zol, stimulates the expansion of Vδ2 T lymphocytes with effector memory phenotype and antitumor cytotoxic activity, besides sensitizing cancer cells to γδ T cell-mediated cytotoxicity.
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Polymerization of Rod-Like Macromolecular Monomers Studied by Stopped-Flow, Multiangle Light Scattering: Set-Up, Data Processing, and Application to Fibrin Formation
TL;DR: An experimental set-up in which a commercial multiangle laser light scattering photometer is linked to a stopped-flow mixer, allowing, in principle, the time-resolved extrapolation of the weight-average molecular weight M(w) and of the z-average square radius of gyration (z) of the polymers from Zimm-like plots.