D
Delia I. Chiarello
Researcher at Pontifical Catholic University of Chile
Publications - 28
Citations - 581
Delia I. Chiarello is an academic researcher from Pontifical Catholic University of Chile. The author has contributed to research in topics: Lipid peroxidation & Red blood cell. The author has an hindex of 10, co-authored 22 publications receiving 345 citations. Previous affiliations of Delia I. Chiarello include Venezuelan Institute for Scientific Research & San Sebastián University.
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Journal ArticleDOI
Oxidative stress: Normal pregnancy versus preeclampsia
Delia I. Chiarello,Cilia Abad,Deliana Rojas,Fernando Toledo,Carmen Vázquez,Alfonso Mate,Luis Sobrevia,Luis Sobrevia,Luis Sobrevia,Reinaldo Marín +9 more
TL;DR: This review focuses on the mechanism of oxidative stress in pregnancy as well as its involvement and consequences on the human pregnancy-specific clinical syndrome preeclampsia.
Journal ArticleDOI
Foetoplacental communication via extracellular vesicles in normal pregnancy and preeclampsia.
Delia I. Chiarello,Rocío Salsoso,Fernando Toledo,Alfonso Mate,Carmen Vázquez,Luis Sobrevia,Luis Sobrevia,Luis Sobrevia +7 more
TL;DR: The role of EVs in human foetomaternal communication in normal pregnancy and preeclampsia is addressed and EVs-mediated signalling to be nearby or distant target cells is addressed.
Journal ArticleDOI
Oxidative stress and mitochondrial dysfunction in early-onset and late-onset preeclampsia.
Reinaldo Marín,Delia I. Chiarello,Cilia Abad,Deliana Rojas,Fernando Toledo,Luis Sobrevia,Luis Sobrevia,Luis Sobrevia +7 more
TL;DR: The mitochondrial dysfunction in both eoPE and loPE is summarized and interventional studies in patients with preeclampsia using the coenzyme Q10, a key molecule in the electron transport chain, suggest that agents increasing the antioxidant capacity of the placenta may be protective of developing preeClampsia.
Journal ArticleDOI
Akt/mTOR Role in Human Foetoplacental Vascular Insulin Resistance in Diseases of Pregnancy.
Roberto Villalobos-Labra,Luis Silva,Mario Subiabre,Joaquin Araos,Rocío Salsoso,Rocío Salsoso,Bárbara Fuenzalida,Tamara Sáez,Fernando Toledo,Fernando Toledo,Marcelo González,Claudia Quezada,Fabián Pardo,Fabián Pardo,Delia I. Chiarello,Andrea Leiva,Luis Sobrevia,Luis Sobrevia,Luis Sobrevia +18 more
TL;DR: A defective signalling via Akt/mTOR in response to insulin is a central and common mechanism of insulin resistance in these diseases of pregnancy.
Journal ArticleDOI
Insulin is a key modulator of fetoplacental endothelium metabolic disturbances in gestational diabetes mellitus
Luis Sobrevia,Rocío Salsoso,Bárbara Fuenzalida,Eric Barros,Lilian Toledo,Luis Silva,Carolina Pizarro,Mario Subiabre,Roberto Villalobos,Joaquin Araos,Fernando Toledo,Marcelo González,Jaime Gutiérrez,Marcelo Farías,Delia I. Chiarello,Fabián Pardo,Andrea Leiva +16 more
TL;DR: It is proposed that insulin is a factor restoring endothelial function in GDM by reversing ERS, hypercholesterolaemia and angiogenesis to a physiological state involving insulin activation of insulin receptor isoforms and adenosine receptors and metabolism in the human placenta from GDM pregnancies.