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Denghong Zhang
Researcher at Xiamen University
Publications - 2
Citations - 359
Denghong Zhang is an academic researcher from Xiamen University. The author has contributed to research in topics: Downregulation and upregulation & Hippocampal formation. The author has an hindex of 1, co-authored 1 publications receiving 104 citations.
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Journal ArticleDOI
Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease.
TL;DR: This work discusses glial dysfunction in AD with emphasis on neuronal and glial receptors that mediate Aβ-induced toxicity, and discusses other critical factors that may affect AD pathogenesis, including genetics, aging, variables related to environment, lifestyle habits, and APOE.
Posted ContentDOI
Downregulating PTBP1 Fails to Convert Astrocytes into Hippocampal Neurons and to Alleviate Symptoms in Alzheimer's Mouse Models
Tiantian Guo,Xinjia Pan,Guangtong Jiang,Denghong Zhang,Jinghui Qi,Lin Shao,Zhanxiang Wang,Huaxi Xu,Yingjun Zhao +8 more
TL;DR: The results do not support some of the recent extraordinary and revolutionary claims that resident astrocytes can be directly and efficiently converted into neurons, and suggest that cell fate conversion strategy for neurodegenerative disease therapy through manipulating one single gene, such as PTBP1, warrants more rigorous scrutiny.