Y
Yingjun Zhao
Researcher at Discovery Institute
Publications - 41
Citations - 2167
Yingjun Zhao is an academic researcher from Discovery Institute. The author has contributed to research in topics: Microglia & Medicine. The author has an hindex of 18, co-authored 31 publications receiving 1336 citations. Previous affiliations of Yingjun Zhao include Sanford-Burnham Institute for Medical Research & Life Sciences Institute.
Papers
More filters
Journal ArticleDOI
TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function
Yingjun Zhao,Xi-Lin Wu,Xiaoguang Li,Lu Lin Jiang,Xun Gui,Yan Liu,Yu Sun,Bing Zhu,Juan C. Piña-Crespo,Muxian Zhang,Ningyan Zhang,Xiaochun Chen,Guojun Bu,Zhiqiang An,Timothy Y. Huang,Huaxi Xu,Huaxi Xu +16 more
TL;DR: TREM2 is demonstrated as a microglial Aβ receptor transducing physiological and AD-related pathological effects associated with Aβ, and TREM2 interaction with its signaling adaptor DAP12 is enhanced by A β, regulating downstream phosphorylation of SYK and GSK3β.
Journal ArticleDOI
Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease.
TL;DR: This work discusses glial dysfunction in AD with emphasis on neuronal and glial receptors that mediate Aβ-induced toxicity, and discusses other critical factors that may affect AD pathogenesis, including genetics, aging, variables related to environment, lifestyle habits, and APOE.
Journal ArticleDOI
Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer???s Disease Models
C.Y. Daniel Lee,C.Y. Daniel Lee,Anthony Daggett,Anthony Daggett,Xiaofeng Gu,Xiaofeng Gu,Lu-Lin Jiang,Peter Langfelder,Xiaoguang Li,Nan Wang,Nan Wang,Yingjun Zhao,Chang Sin Park,Chang Sin Park,Yonatan A. Cooper,Yonatan A. Cooper,Isabella Ferando,Istvan Mody,Giovanni Coppola,Huaxi Xu,X. William Yang,X. William Yang +21 more
TL;DR: This study shows that a genomic transgene-driven increase in TREM2 expression reprograms microglia responsivity and ameliorates neuropathological and behavioral deficits in AD mouse models.
Journal ArticleDOI
Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome
Xin Wang,Yingjun Zhao,Yingjun Zhao,Xiaofei Zhang,Hedieh Badie,Ying Zhou,Yangling Mu,Li Shen Loo,Lei Cai,Robert C. Thompson,Bo Yang,Yaomin Chen,Peter F. Johnson,Chengbiao Wu,Guojun Bu,William C. Mobley,Dongxian Zhang,Fred H. Gage,Barbara Ranscht,Yun-wu Zhang,Yun-wu Zhang,Stuart A. Lipton,Stuart A. Lipton,Wanjin Hong,Wanjin Hong,Huaxi Xu,Huaxi Xu +26 more
TL;DR: The identification of the role of SNX27 in synaptic function establishes a new molecular mechanism of Down's syndrome pathogenesis and rescues synaptic and cognitive deficits.
Journal ArticleDOI
M1 muscarinic acetylcholine receptor in Alzheimer's disease.
Shangtong Jiang,Yanfang Li,Cuilin Zhang,Yingjun Zhao,Guojun Bu,Huaxi Xu,Huaxi Xu,Yun-wu Zhang +7 more
TL;DR: Recent progress in understanding the functional involvement of M1 mAChR in AD pathology and in developing M1mA cholinergic receptor agonists for AD treatment are reviewed.