H
Huaxi Xu
Researcher at Xiamen University
Publications - 231
Citations - 22898
Huaxi Xu is an academic researcher from Xiamen University. The author has contributed to research in topics: Presenilin & Medicine. The author has an hindex of 71, co-authored 198 publications receiving 19191 citations. Previous affiliations of Huaxi Xu include Albert Einstein College of Medicine & Central South University.
Papers
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Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
TL;DR: The A β-dependent and Aβ-independent mechanisms that link Apo-E4 status with AD risk are discussed, and how to design effective strategies for AD therapy by targeting ApO-E is considered.
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Intraneuronal Aβ42 Accumulation in Human Brain
Gunnar K. Gouras,Gunnar K. Gouras,Julia Tsai,Jan Näslund,Bruno Vincent,Mark A. Edgar,Frédéric Checler,Jeffrey P. Greenfield,Vahram Haroutunian,Joseph D. Buxbaum,Huaxi Xu,Paul Greengard,Norman R. Relkin +12 more
TL;DR: It is suggested that intracellular Aβ42 accumulation is an early event in neuronal dysfunction and that preventing intraneuronal A β42 aggregation may be an important therapeutic direction for the treatment of AD.
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APP processing in Alzheimer's disease
TL;DR: Current knowledge of APP processing regulation as well as the patho/physiological functions of APP and its metabolites are reviewed.
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Intraneuronal Alzheimer Aβ42 Accumulates in Multivesicular Bodies and Is Associated with Synaptic Pathology
Reisuke H. Takahashi,Reisuke H. Takahashi,Teresa A. Milner,Feng Li,Ellen E. Nam,Mark A. Edgar,Haruyasu Yamaguchi,M. Flint Beal,Huaxi Xu,Paul Greengard,Gunnar K. Gouras,Gunnar K. Gouras +11 more
TL;DR: Using immunoelectron microscopy, it is reported that beta-amyloid 42 localized predominantly to multivesicular bodies of neurons in normal mouse, rat, and human brain, and in brains from Alzheimer transgenic mice and human Alzheimer brain.
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Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides.
Huaxi Xu,Gunnar K. Gouras,Jeffrey P. Greenfield,Bruno Vincent,Jan Näslund,Louis Mazzarelli,Gabriel Fried,Jasmina N. Jovanovic,Mary Seeger,Norman R. Relkin,Francesca-Fang Liao,Frédéric Checler,Joseph D. Buxbaum,Brian T. Chait,Gopal Thinakaran,Sangram S. Sisodia,Rong Wang,Paul Greengard,S.E. Gandy +18 more
TL;DR: Evidence is presented that physiological levels of 17β-estradiol reduce the generation of Aβ by neuroblastoma cells and by primary cultures of rat, mouse and human embryonic cerebrocortical neurons that suggest a mechanism by which estrogen replacement therapy can delay or prevent AD.