Denice C. Bay

TL;DR: Preliminary data support the notion that introns usually do not interrupt structural protein motifs, namely the predicted β-strands, and concur with the concept of exon shuffling, wherein exons encode structural modules of proteins and the loss and gain of introns and the shuffling of exons via recombination events contribute to the complexity of modern day proteomes.

TL;DR: Olin—a 3ʹ→5ʹ exonuclease highly conserved among Actinobacteria, Beta-, Delta- and Gammaproteobacteria—is identified as the primary enzyme responsible for pGpG degradation in Pseudomonas aeruginosa cells, revealing that nanoribonucleases, which have been considered housekeeping proteins crucial for mRNA turnover, also have a key role in c-di-GMP signaling.

TL;DR: Omadacycline possesses broad-spectrum antibacterial activity against Gram-positive and Gram-negative aerobic, anaerobic, and atypical bacteria, and remains active against bacterial isolates possessing common tetracyCline resistance mechanisms such as efflux pumps and ribosomal protection proteins.

TL;DR: In this article, the authors compared E. coli K-12 single MDT gene deletion strains in minimal and rich media and found that deletion of MDTs resulted in significant reductions in both planktonic and biofilm growth phenotypes and enhanced antimicrobial susceptibilities.

TL;DR: A review of a growing number of single component TolC-independent multidrug resistant efflux pumps specifically associated with biocide resistance that are rapidly spread between members of Enterobacteriaceae on conjugative plasmids and mobile genetic elements, emphasizing their importance to antimicrobial resistance.