J
Joe J. Harrison
Researcher at University of Calgary
Publications - 61
Citations - 6993
Joe J. Harrison is an academic researcher from University of Calgary. The author has contributed to research in topics: Biofilm & Pseudomonas aeruginosa. The author has an hindex of 32, co-authored 54 publications receiving 5622 citations. Previous affiliations of Joe J. Harrison include University of Washington.
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Journal ArticleDOI
Antimicrobial activity of metals: mechanisms, molecular targets and applications
TL;DR: The chemical and toxicological principles that underlie the antimicrobial activity of metals are described and the preferences of metal atoms for specific microbial targets are discussed.
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Multimetal resistance and tolerance in microbial biofilms.
TL;DR: A multifactorial model by which biofilm populations can withstand metal toxicity by a process of cellular diversification is proposed.
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The extracellular matrix protects Pseudomonas aeruginosa biofilms by limiting the penetration of tobramycin.
Boo Shan Tseng,Wei Zhang,Joe J. Harrison,Tam P. Quach,Jisun L. Song,Jon Penterman,Jon Penterman,Pradeep K. Singh,David L. Chopp,Aaron I. Packman,Matthew R. Parsek +10 more
TL;DR: It is proposed that tobramycin sequestration at the biofilm periphery is an important mechanism in protecting metabolically active cells that lie just below the zone of sequestration.
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Precision-engineering the Pseudomonas aeruginosa genome with two-step allelic exchange
Laura R. Hmelo,Bradley R. Borlee,Henrik Almblad,Michelle E. Love,Trevor E. Randall,Boo Shan Tseng,Chuyang Lin,Yasuhiko Irie,Kelly M. Storek,Jaeun Yang,Richard Siehnel,P. Lynne Howell,Pradeep K. Singh,Tim Tolker-Nielsen,Matthew R. Parsek,Herbert P. Schweizer,Joe J. Harrison +16 more
TL;DR: This protocol describes the use of this technique to make gene knockouts and knock-ins, as well as single-nucleotide insertions, deletions and substitutions, in Pseudomonas aeruginosa.
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Psl trails guide exploration and microcolony formation in Pseudomonas aeruginosa biofilms.
Kun Zhao,Boo Shan Tseng,Bernard Beckerman,Fan Jin,Maxsim Gibiansky,Joe J. Harrison,Erik Luijten,Matthew R. Parsek,Gerard C. L. Wong +8 more
TL;DR: This Pareto-type behaviour indicates that the bacterial community self-organizes in a manner analogous to a capitalist economic system, a ‘rich-get-richer’ mechanism of Psl accumulation that results in a small number of ‘elite’ cells becoming extremely enriched in communally produced Psl.