D
Denise Drazul-Schrader
Researcher at Children's Hospital of Philadelphia
Publications - 11
Citations - 1038
Denise Drazul-Schrader is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Cholesterol & Efflux. The author has an hindex of 8, co-authored 11 publications receiving 932 citations.
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Journal ArticleDOI
The Ability to Promote Efflux Via ABCA1 Determines the Capacity of Serum Specimens With Similar High-Density Lipoprotein Cholesterol to Remove Cholesterol From Macrophages
Margarita de la Llera-Moya,Denise Drazul-Schrader,Bela F. Asztalos,Marina Cuchel,Daniel J. Rader,George H. Rothblat +5 more
TL;DR: It is found that independently of HDL-C, sera with higher efflux capacity had a significant increase in ABCA1-mediated efflux, which was significantly correlated to the concentration of pre&bgr;-1 HDL.
Cell Biology/Signaling The Ability to Promote Efflux Via ABCA1 Determines the Capacity of Serum Specimens With Similar High-Density Lipoprotein Cholesterol to Remove Cholesterol From Macrophages
Margarita de la Llera-Moya,Denise Drazul-Schrader,Bela F. Asztalos,Marina Cuchel,Daniel J. Rader,George H. Rothblat +5 more
TL;DR: In this article, the authors measured efflux from macrophages to apolipoprotein B-depleted serum from 263 specimens and found instances in which serum having similar high-density lipoprotein cholesterol (HDL-C) differed in their efflux capacity.
Journal ArticleDOI
L-Carnitine intake and high trimethylamine N-oxide plasma levels correlate with low aortic lesions in ApoE(-/-) transgenic mice expressing CETP.
Heidi L. Collins,Denise Drazul-Schrader,Anthony C. Sulpizio,Paul D. Koster,Yuping Williamson,Steven J. Adelman,Kevin Owen,Toran Sanli,Aouatef Bellamine +8 more
TL;DR: It is suggested that TMAO slows aortic lesion formation in this mouse model and may have a protective effect against atherosclerosis development in humans.
Journal ArticleDOI
Serum albumin acts as a shuttle to enhance cholesterol efflux from cells
Sandhya Sankaranarayanan,Margarita de la Llera-Moya,Denise Drazul-Schrader,Michael C. Phillips,Ginny Kellner-Weibel,George H. Rothblat +5 more
TL;DR: Synergistic efflux was obtained when LPDS was incubated with cells and LDL, and a synergistic effect was also obtained when RBC was used as the sink and albumin as shuttle.
Journal ArticleDOI
Separation of Lipid Transport Functions by Mutations in the Extracellular Domain of Scavenger Receptor Class B, Type I*
Margery A. Connelly,Margarita de la Llera-Moya,Yinan Peng,Denise Drazul-Schrader,George H. Rothblat,David L. Williams +5 more
TL;DR: Findings uncover a difference in the SR-BI-mediated efflux pathways for FC transfer to HDL acceptors versus phospholipid vesicles and the loss of the cholesterol oxidase-sensitive FC pool and FC efflux to small unilamellar vesicle acceptors in Class 4 mutants suggests that these activities may be mechanistically related.