M
Marina Cuchel
Researcher at University of Pennsylvania
Publications - 111
Citations - 9634
Marina Cuchel is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Familial hypercholesterolemia & Cholesterol. The author has an hindex of 30, co-authored 98 publications receiving 7868 citations. Previous affiliations of Marina Cuchel include Hospital of the University of Pennsylvania.
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Journal ArticleDOI
Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis
Amit Khera,Marina Cuchel,Margarita de la Llera-Moya,Amrith Rodrigues,Megan F. Burke,Kashif Jafri,Benjamin French,Julie A. Phillips,Megan L. Mucksavage,Robert L. Wilensky,Emile R. Mohler,George H. Rothblat,Daniel J. Rader +12 more
TL;DR: Cholesterol efflux capacity from macrophages, a metric of HDL function, has a strong inverse association with both carotid intima-media thickness and the likelihood of angiographic coronary artery disease, independently of the HDL cholesterol level.
Journal ArticleDOI
Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society
Marina Cuchel,Eric Bruckert,Henry N. Ginsberg,Frederick J. Raal,Raul D. Santos,Robert A. Hegele,Jan Albert Kuivenhoven,Børge G. Nordestgaard,Olivier S. Descamps,Elisabeth Steinhagen-Thiessen,Anne Tybjærg-Hansen,Gerald F. Watts,Maurizio Averna,Catherine Boileau,Jan Borén,A.L. Catapano,Joep C. Defesche,G. Kees Hovingh,Steve E. Humphries,Petri T. Kovanen,Luis Masana,Päivi Pajukanta,Klaus G. Parhofer,Kausik K. Ray,Anton F. H. Stalenhoef,Erik S.G. Stroes,Marja-Riitta Taskinen,Albert Wiegman,Olov Wiklund,M. John Chapman +29 more
TL;DR: In this article, the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society (EAS) critically reviewed available data with the aim of providing clinical guidance for the recognition and management of HoFH.
Journal ArticleDOI
Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study.
Marina Cuchel,Emma A. Meagher,Hendrik Du Toit Theron,Dirk J. Blom,Dirk J. Blom,A. David Marais,A. David Marais,Robert A. Hegele,Maurizio Averna,Cesare R. Sirtori,Prediman K. Shah,Daniel Gaudet,Claudia Stefanutti,Giovanni Battista Vigna,Anna M. E. Du Plessis,Kathleen J. Propert,William J. Sasiela,LeAnne T. Bloedon,Daniel J. Rader +18 more
TL;DR: Treatment with lomitapide could be a valuable drug in the management of homozygous familial hypercholesterolaemia, according to the FDA Office of the Orphan Product Development.
Journal ArticleDOI
Familial Hypercholesterolaemia in Children and Adolescents: Gaining Decades of Life by Optimizing Detection and Treatment
Albert Wiegman,Samuel S. Gidding,Gerald F. Watts,M. John Chapman,Henry N. Ginsberg,Marina Cuchel,Leiv Ose,Maurizio Averna,Catherine Boileau,Jan Borén,Eric Bruckert,Alberico L. Catapano,Joep C. Defesche,Olivier S. Descamps,Robert A. Hegele,G. Kees Hovingh,Steve E. Humphries,Petri T. Kovanen,Jan Albert Kuivenhoven,Luis Masana,Børge G. Nordestgaard,Päivi Pajukanta,Klaus G. Parhofer,Frederick J. Raal,Kausik K. Ray,Raul D. Santos,Anton F. H. Stalenhoef,Elisabeth Steinhagen-Thiessen,Erik S.G. Stroes,Marja-Riitta Taskinen,Marja-Riitta Taskinen,Anne Tybjærg-Hansen,Olov Wiklund +32 more
TL;DR: This consensus paper aims to improve awareness of the need for early detection and management of FH children by recommending cascade screening of families using a combined phenotypic and genotypic strategy.
Journal ArticleDOI
Macrophage Reverse Cholesterol Transport Key to the Regression of Atherosclerosis
Marina Cuchel,Daniel J. Rader +1 more
TL;DR: The relationship of RCT to atherosclerosis remains more of a hypothesis than an established fact, as in atherosclerotic lesions, the primary cell type that is overloaded with cholesterol is the macrophage, and therefore, it makes more sense to conceptualize and measure RCT as a Macrophage-specific phenomenon.