D
Denise R. Cooper
Researcher at University of South Florida
Publications - 111
Citations - 6370
Denise R. Cooper is an academic researcher from University of South Florida. The author has contributed to research in topics: Protein kinase C & Insulin. The author has an hindex of 39, co-authored 110 publications receiving 6076 citations. Previous affiliations of Denise R. Cooper include Veterans Health Administration & United States Department of Veterans Affairs.
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Journal ArticleDOI
Insulin provokes apparent increases in rat adipocyte M-kinase
TL;DR: Findings suggest that insulin provokes increases in M-kinase in rat adipocytes, and this finding is consistent with previous work on the role of EMT inhibitory regulation of PKC activity in adipocytes.
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Further Evidence Implicating Diacylglycerol Generation and Protein Kinase C Activation in Agonist-Induced Increases in Glucose Uptake: Insulin-Like Effects of Phenylephrine in BC3H-1 Myocytes
Robert V. Farese,N K Rosic,Mary L. Standaert,J. S. Babischkin,Denise R. Cooper,John S. Davis,R J Pollet +6 more
TL;DR: The hypothesis that diacylglycerol generation and protein kinase C activation may be important in the stimulation of glucose uptake by agents such as phenylephrine and insulin that activate the phosphoinositide cycle is supported.
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Transformer 2β homolog (Drosophila) (TRA2B) Regulates Protein Kinase C δI (PKCδI) Splice Variant Expression during 3T3L1 Preadipocyte Cell Cycle
TL;DR: KCδI is a gate-keeper of adipocyte differentiation and is required for mitotic clonal expansion of preadipocytes in adipogenesis, and the splice factor TRA2B regulates alternative splicing of PKC δI during adipogenesis.
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Effects of Interferon and PKC Modulators on Human Glioma Protein Kinase C, Cell Proliferation, and Cell Cycle
TL;DR: The in-vitro effects of human interferon α-2b, protein kinase C (PKC) agonist, TPA and PKC inhibitor (calphostin C) on human glioma PKC activity, cell proliferation and cell cycle were compared and it is concluded that HuIFN α- 2b's mode of action may be directly or indirectly affecting PKC.
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Protein kinase C(19–31) pseudosubstrate inhibition of insulin action in rat adipocytes
TL;DR: Treatment of intact adipocytes with the autoregulatory PKC pseudosubstrate PKC inhibited insulin‐stimulated hexose uptake and lipogenesis, with no effect on basal values, indicating that PKC may play a role in the mediation of insulin action in adipocytes.