Dennis Doleschel

TL;DR: This review summarizes important steps in the development of US CAs and introduces the current clinical applications of contrast-enhanced US, including an overview of the recent developments in US probe design for functional and molecular diagnosis as well as for drug delivery.

TL;DR: The results identify direct angiostatic and antifibrotic effects of the Cxcr3 ligand Cxcl9 in a model of experimental liver fibrosis and suggest that the amelioration of liver damage by systemic application of CxCl9 might offer a novel therapeutic approach for chronic liver diseases associated with increased neoangiogenesis.

TL;DR: The synergistic inhibitory effects of dual immune checkpoint inhibition can be explained by anti-tumorigenic T cell responses mediated by CTLA-4 inhibition and M1 macrophage polarization predominantly induced by PD-L1 blockade.

TL;DR: The failure of annexin-based apoptosis assessment in vivo can be explained by the significant breakdown of the vasculature after therapy, resulting in reduced probe/tracer delivery.

TL;DR: A protocol for multimodal µCT-FMT imaging including the image processing steps necessary to extract quantitative measurements is described and the applicability of the method is shown by assessing the biodistribution of a well-known probe that binds to bones and joints.