C
Christoph Kuppe
Researcher at RWTH Aachen University
Publications - 66
Citations - 1974
Christoph Kuppe is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 15, co-authored 48 publications receiving 1094 citations. Previous affiliations of Christoph Kuppe include Martin Luther University of Halle-Wittenberg & Erasmus University Rotterdam.
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Journal ArticleDOI
Decoding myofibroblast origins in human kidney fibrosis
Christoph Kuppe,Mahmoud M. Ibrahim,Mahmoud M. Ibrahim,Jennifer Kranz,Jennifer Kranz,Xiaoting Zhang,Susanne Ziegler,Javier Perales-Patón,Javier Perales-Patón,Jitske Jansen,Jitske Jansen,Jitske Jansen,Katharina C Reimer,James R Smith,Ross Dobie,John R. Wilson-Kanamori,Maurice Halder,Yaoxian Xu,Nazanin Kabgani,Nadine Kaesler,Martin Klaus,Lukas Gernhold,Victor G. Puelles,Victor G. Puelles,Tobias B. Huber,Peter Boor,Sylvia Menzel,Remco Hoogenboezem,Eric Bindels,Joachim Steffens,Jürgen Floege,Rebekka K. Schneider,Rebekka K. Schneider,Julio Saez-Rodriguez,Julio Saez-Rodriguez,Julio Saez-Rodriguez,Neil C. Henderson,Rafael Kramann,Rafael Kramann +38 more
TL;DR: Using single-cell RNA sequencing, the transcriptomes of cells from the proximal and non-proximal tubules of healthy and fibrotic human kidneys are profiled to map the entire human kidney and identify distinct subpopulations of pericytes and fibroblasts as the main cellular sources of scar-forming myofibro Blasts during human kidney fibrosis.
Journal ArticleDOI
Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease.
Rafael Kramann,Rafael Kramann,Claudia Goettsch,Janewit Wongboonsin,Hiroshi Iwata,Rebekka K. Schneider,Christoph Kuppe,Nadine Kaesler,Monica Chang-Panesso,Flavia Gomes Machado,Susannah Gratwohl,Kaushal Madhurima,Joshua D. Hutcheson,Sanjay Jain,Elena Aikawa,Benjamin D. Humphreys +15 more
TL;DR: It is shown that Gli1+ cells located in the arterial adventitia are progenitors of vascular smooth muscle cells and contribute to neointima formation and repair after acute injury to the femoral artery.
Journal ArticleDOI
Parietal Epithelial Cells Participate in the Formation of Sclerotic Lesions in Focal Segmental Glomerulosclerosis
Bart Smeets,Christoph Kuppe,Eva Maria Sicking,Astrid Fuss,Peggy Jirak,Toin H. van Kuppevelt,Karlhans Endlich,Jack F.M. Wetzels,Hermann Josef Gröne,Jürgen Floege,Marcus J. Moeller +10 more
TL;DR: It is demonstrated that PECs contribute to the development and progression of the sclerotic lesions that define FSGS, but this pathogenesis may be relevant to all etiologies of glomerulosclerosis.
Journal ArticleDOI
Chemokine Cxcl9 attenuates liver fibrosis-associated angiogenesis in mice.
H Sahin,Erawan Borkham-Kamphorst,Christoph Kuppe,Mirko Moreno Zaldivar,Christoph Grouls,M Alsamman,A Nellen,P. Schmitz,D Heinrichs,Marie-Luise Berres,Dennis Doleschel,D. Scholten,Ralf Weiskirchen,Marcus J. Moeller,Fabian Kiessling,Christian Trautwein,Hermann E. Wasmuth +16 more
TL;DR: The results identify direct angiostatic and antifibrotic effects of the Cxcr3 ligand Cxcl9 in a model of experimental liver fibrosis and suggest that the amelioration of liver damage by systemic application of CxCl9 might offer a novel therapeutic approach for chronic liver diseases associated with increased neoangiogenesis.
Posted ContentDOI
Spatial multi-omic map of human myocardial infarction
Christoph Kuppe,Christoph Kuppe,Ramirez Flores Ro,Zhijian Li,Hannani M,Hannani M,Jovan Tanevski,Maurice Halder,Mingbo Cheng,Susanne Ziegler,Xue-Xian Zhang,Preisker F,Nadine Kaesler,Xu Y,Remco Hoogenboezem,Eric M.J. Bindels,Rebekka K. Schneider,Rebekka K. Schneider,Milting H,Ivan G. Costa,Julio Saez-Rodriguez,Julio Saez-Rodriguez,Rafael Kramann,Rafael Kramann +23 more
TL;DR: This study identified and validated mechanisms of fibroblast to myofibroblast differentiation that drive cardiac fibrosis and provides an integrative molecular map of human myocardial infarction and represents a reference to advance mechanistic and therapeutic studies of cardiac disease.