Denny Sakkas

TL;DR: The mechanisms responsible for DNA fragmentation in human sperm, including those occurring during spermatogenesis and transport through the reproductive tract are reviewed, and how abnormal sperm could be dealt with by the oocyte and how sperm DNA abnormalities may interfere with normal embryo and fetal development are discussed.

TL;DR: The possible origins of DNA damage in ejaculated human spermatozoa are discussed, how these spermutozoa arrive in the ejaculate of some men, and what consequences they may have if they succeed in their genetic project are discussed.

TL;DR: It is proposed that the presence of DNA damage is not directly linked to an apoptotic process occurring in spermatozoa and arises due to problems in the nuclear remodeling process, and may be linked to defects in cytoplasmic remodeling during the later stages of spermatogenesis.

TL;DR: The extent of nuclear DNA fragmentation in prepared ejaculated spermatozoa used in IVF negatively correlates with blastocyst development.

TL;DR: There was a significant increase in OPR per embryo transfer with the use of PGT-A in the subgroup of women aged 35-40 years who had two or more embryos that could be biopsied, but this was not significant when analyzed by ITT.