S
Santiago Munné
Researcher at Yale University
Publications - 133
Citations - 6738
Santiago Munné is an academic researcher from Yale University. The author has contributed to research in topics: Preimplantation genetic diagnosis & Aneuploidy. The author has an hindex of 40, co-authored 133 publications receiving 6240 citations. Previous affiliations of Santiago Munné include NewYork–Presbyterian Hospital & University of California, Irvine.
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Journal ArticleDOI
Embryo morphology, developmental rates, and maternal age are correlated with chromosome abnormalities*
TL;DR: It is demonstrated that, in morphologically and developmentally normal human embryos, cleavage-stage aneuploidy significantly increases with maternal age, and the results suggest that implantation failure in older women largely could be due to aneuPLoidy.
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Diagnosis of major chromosome aneuploidies in human preimplantation embryos.
TL;DR: A short fluorescence in-situ hybridization procedure using fluorochrome and digoxigenin labelled DNA probes was developed for application in human preimplantation embryos in order to analyse the five chromosomes most involved in human aneuploidy.
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Developmental ability of chromosomally abnormal human embryos to develop to the blastocyst stage
TL;DR: Even though there is a strong selection against chromosomally abnormal embryos, extended culture to day 5 or 6 cannot be used as a reliable tool to select against clinically relevant chromosome abnormalities such as trisomies.
Journal ArticleDOI
Preimplantation genetic testing for aneuploidy versus morphology as selection criteria for single frozen-thawed embryo transfer in good-prognosis patients: a multicenter randomized clinical trial.
Santiago Munné,Brian Kaplan,John L. Frattarelli,Tim Child,Gary S. Nakhuda,F. Nicholas Shamma,Kaylen M. Silverberg,Tasha Kalista,Alan H. Handyside,Mandy G. Katz-Jaffe,Dagan Wells,Tony Gordon,Sharyn Stock-Myer,S.P. Willman,Brian D Acacio,Stuart Lavery,Anna Carby,Robert Boostanfar,Robert Forman,Mark Sedler,Anthea Jackson,Keith Jordan,William B. Schoolcraft,S. McReynolds,Vicki L. Schnell,Randall A. Loy,Samuel J. Chantilis,Lowell Ku,John L. Frattarelli,Arlene J. Morales,H. Randall Craig,Mark Perloe,Craig A. Witz,Wei-Hua Wang,J. Wilcox,J.M. Norian,Stephanie Marshall Thompson,Serena Chen,John Garrisi,Renee Walmsley,Robert J. Mendola,Samuel Pang,Denny Sakkas,Kristin L. Rooney,Rita Sneeringer,M.J. Glassner,Leeanda Wilton,Mirjana Martic,Peter Coleman,Stephanie Shepley,Ginny Mounce,Tracey Griffiths,Ronald F. Feinberg,Keith L. Blauer,Brett Reggio,Rachel Rhinehart,William F. Ziegler,Hina Ahmed,Scott Kratka,Evan M. Rosenbluth,K. Ivani,Angela C. Thyer,T. Minter,Charles M. Miller,Mathias Gysler,Pauline Saunders,Robert F. Casper,Deirdre A. Conway,Mark R. Hughes,Michael Large,Joshua Blazek,Elpida Fragouli,Samer Alfarawati +72 more
TL;DR: There was a significant increase in OPR per embryo transfer with the use of PGT-A in the subgroup of women aged 35-40 years who had two or more embryos that could be biopsied, but this was not significant when analyzed by ITT.
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Chromosome mosaicism in human embryos.
TL;DR: To assess the stage at which mosaicism occurred in preimplantation human embryos through use of fluorescence in situ hybridization (FISH) with multiple probes, full karyotypes of blastomeres from 2- to 8-cell human embryos are obtained.