Background: Two COX isoenzymes are known, COX-1 and COX-2, for which the main inhibitors are the NSAIDs. The common anti-inflammatory drugs (such as aspirin, ibuprofen and naproxen) all act by blocking the action of both the COX-1 and COX-2 enzymes. The COX-2 inhibitors represent a new class of drugs that do not affect COX-1 but selectively block COX-2. This selective action provides the benefits of reducing inflammation without irritating the stomach and cardiovascular effects. Objective: This review focuses on patents published in the field during 2002 – 2008, paying particular attention to promising COX-2 inhibitors. Conclusion: Structural analogues of the COX-2 inhibitors celecoxib and valdecoxib, and novel potential pyridazine, triazole, indole and thione derivatives emerge as promising leads for the treatment of inflammation, pain and other diseases.

The search for new COX-2 inhibitors: a review of 2002 - 2008 patents.

The subject matter described herein includes methods, systems, and computer program products for routing ENUM queries to an ENUM database. According to one aspect, the subject matter described herein includes a method for routing ENUM queries to an ENUM database. The method includes receiving an ENUM query including a subscriber identifier. An ENUM database is identified among a plurality of non-identically provisioned ENUM databases based on the subscriber identifier. The ENUM query is routed to the identified ENUM database.

Methods, systems and computer program products for routing and processing enum queries

We designed a series of specifically deuterated benzopyran analogues as new COX-2 inhibitors with the aim of improving their pharmacokinetic properties. As expected, the deuterated compounds retained potency and selectivity for COX-2. The new molecules possess improved pharmacokinetic profiles in rats compared to their nondeuterated congeners. Most importantly, the new compounds showed pharmacodynamic efficacy in several murine models of inflammation and pain. The benzopyran derivatives were separated into their enantiomers, and the activity was found to reside with the S-isomers. To streamline the synthesis of the desired S-isomers, an organocatalytic asymmetric domino oxa-Michael/aldol condensation reaction was developed for their preparation.

Synthesis of Deuterated Benzopyran Derivatives as Selective COX-2 Inhibitors with Improved Pharmacokinetic Properties.

Compounds useful as Rho kinase inhibitors according to formula IA or IB: wherein A, B, D, E, R1, R2 and Ar1 are as defined herein, and any tautomer, salt, stereoisomer, hydrate, solvent, or prodrug thereof, pharmaceutical compositions, methods of treatment, and synthetic methods are provided.

Benzimidazoles and analogs as rho kinase inhibitors

Methods, systems, and computer readable media for routing a message service message through a communications network are disclosed. In one embodiment, the method includes, at a signaling node upstream from a sending party message server, receiving a message service message that includes a sending party identifier and a receiving party identifier. A number translation database is queried to determine a routing identifier associated with the receiving party identifier. The method also includes modifying the message service message to include the routing identifier, and routing the message service message to the sending party message server.

Methods, systems, and computer readable media for routing a message service message through a communications network

The subject invention concerns methods and compounds that have utility in the treatment of a condition associated with cyclooxygenase-2 mediated disorders. Compounds of particular interest are benzopyrans and their analogs defined by formula (1). Wherein Z, X, R1, R2, R3, and R4 are as described in specification.

Benzopyran compounds useful for treating inflammatory conditions

The subject invention concerns methods and compounds that have utility in the treatment of a condition associated with cyclooxygenase-2 mediated disorders. Compounds of particular interest are benzopyrans and their analogs defined by formula (I). Wherein Z, X, R1, R2, R3, and R4 are as described in the specification.

Chromene derivatives as anti-inflammatory agents

The subject invention concerns methods and compounds that have utility in the treatment of a condition associated with cyclooxygenase-2 mediated disorders. Compounds of particular interest are benzopyrans and their analogs defined by formula 1 
Wherein Z, X, R 1 , R 2 , R 3 , and R 4 are as described in the specification.

Deprow Angela

Papers

Benzopyran compounds useful for treating inflammatory conditions

Chromene derivatives as anti-inflammatory agents

Benzopyran compounds for use in the treatment and prevention of inflammation related conditions

Benzopyranverbindingen toepasbaar voor het behandelen van ontstekingsaandoeningen.

Benzopyranverbindingen voor gebruik bij de behandeling en preventie van ontstekingsgerelateerde aandoeningen.