Liao Subo

TL;DR: In this Letter, the structure-activity relationships, optimization of design, testing criteria, and human half-life data for a series of selective COX-2 inhibitors are provided.

TL;DR: The subject of as discussed by the authors concerns methods and compounds that have utility in the treatment of a condition associated with cyclooxygenase-2 mediated disorders, and the compounds of particular interest are benzopyrans and their analogs defined by formula (1).

TL;DR: New potent and selective lead compounds with improved metabolic properties were identified and binding free energies predicted by free energy perturbation theory yielded good agreement with experimental results.

TL;DR: An elegant solid-phase synthetic route of pyrazolo[3,4d]pyrimidine derivatives via Aza-Wittig/electrocyclic ring closure reaction was developed and validated as discussed by the authors.

TL;DR: In this article, the subject invention concerns methods and compounds that have utility in the treatment of a condition associated with cyclooxygenase-2 mediated disorders, and compounds of particular interest are benzopyrans and their analogs defined by formula (I).