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Derek John Falconer
Researcher at Pfizer
Publications - 8
Citations - 935
Derek John Falconer is an academic researcher from Pfizer. The author has contributed to research in topics: Fluconazole & Candida albicans. The author has an hindex of 7, co-authored 8 publications receiving 870 citations.
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Journal ArticleDOI
Candida albicans Mutations in the Ergosterol Biosynthetic Pathway and Resistance to Several Antifungal Agents
TL;DR: These studies showed that erg11/erg11 mutants of a C. albicans strain harboring a defective erg11 allele can be obtained in vitro in the presence of amphotericin B, and could therefore be selected by similar mechanisms during antifungal therapy.
Journal ArticleDOI
Mechanism of fluconazole resistance in Candida krusei.
Alison S. Orozco,Lindsey M. Higginbotham,Christopher A. Hitchcock,Tanya Parkinson,Derek John Falconer,Ashraf S. Ibrahim,Mahmoud A. Ghannoum,Mahmoud A. Ghannoum,Scott G. Filler,Scott G. Filler +9 more
TL;DR: Analysis of sterols of organisms grown in the absence and presence of fluconazole demonstrated that the predominant sterol of C. krusei is ergosterol and that fluconAZole inhibits 14α-demethylase in this organism.
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Fluconazole resistance associated with drug efflux and increased transcription of a drug transporter gene, PDH1, in Candida glabrata.
Haruko Miyazaki,Yoshitsugu Miyazaki,Antonia Geber,Antonia Geber,Tanya Parkinson,Christopher A. Hitchcock,Derek John Falconer,Douglas J. Ward,Katherine Marsden,John E. Bennett +9 more
TL;DR: In this paper, the earliest azole-susceptible isolate of C. glabrata from this patient was exposed to fluconazole, increased transcripts of the PDR5 homolog appeared, linking azole exposure to regulation of this gene.
Journal ArticleDOI
Fluconazole resistance due to energy-dependent drug efflux in Candida glabrata.
TL;DR: Energy-dependent efflux of fluconazole, possibly via a multidrug resistance-type transporter, is identified as the mechanism of resistance to flu Conazole in C. glabrata.
Journal ArticleDOI
Cloning, sequencing, expression and allelic sequence diversity of erg3 (c-5 sterol desaturase gene) in candida albicans
Yoshitsugu Miyazaki,Antonia Geber,Haruko Miyazaki,Derek John Falconer,Tanya Parkinson,Christopher A. Hitchcock,Brian T. Grimberg,Katherine Nyswaner,John E. Bennett +8 more
TL;DR: The C-5 sterol desaturase gene (ERG3), essential for yeast ergosterol biosynthesis, was cloned and sequenced from Candida albicans by homology with the Saccharomyces cerevisiae ERG3 to look for changes that might explain the erg3 phenotype.