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Brian T. Grimberg
Researcher at Case Western Reserve University
Publications - 33
Citations - 1799
Brian T. Grimberg is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Plasmodium falciparum & Malaria. The author has an hindex of 17, co-authored 33 publications receiving 1645 citations. Previous affiliations of Brian T. Grimberg include Wake Forest University & National Institutes of Health.
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Journal ArticleDOI
Plasmodium vivax clinical malaria is commonly observed in Duffy-negative Malagasy people
Didier Menard,Céline Barnadas,Christiane Bouchier,Cara N. Henry-Halldin,Laurie R. Gray,Arsène Ratsimbasoa,Vincent Thonier,Jean François Carod,Olivier Domarle,Yves Colin,Olivier F. Bertrand,Julien Picot,Christopher L. King,Brian T. Grimberg,Odile Mercereau-Puijalon,Peter A. Zimmerman +15 more
TL;DR: Findings established a paradigm that P. vivax has broken through its dependence on the Duffy antigen for establishing human blood-stage infection and disease in association with Duffy blood group polymorphism in Madagascar.
Journal ArticleDOI
Plasmodium vivax invasion of human erythrocytes inhibited by antibodies directed against the Duffy binding protein
Brian T. Grimberg,Rachanee Udomsangpetch,Jia Xainli,Amy M. McHenry,Tasanee Panichakul,Jetsumon Sattabongkot,Liwang Cui,Moses J. Bockarie,Chetan E. Chitnis,John H. Adams,Peter A. Zimmerman,Christopher L. King,Christopher L. King +12 more
TL;DR: These results show, for what is believed to be the first time, that both rabbit and human antibodies directed against PvDBPII reduce invasion efficiency of wild P. vivax isolated from infected patients, and suggest that a Pv DBP-based vaccine may reduce human blood-stage P.vivax infection.
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Reduced Risk of Plasmodium vivax Malaria in Papua New Guinean Children with Southeast Asian Ovalocytosis in Two Cohorts and a Case-Control Study
Anna Rosanas-Urgell,Enmoore Lin,Laurens Manning,Patricia Rarau,Moses Laman,Nicolas Senn,Brian T. Grimberg,Livingstone Tavul,Danielle I. Stanisic,Leanne J. Robinson,John J. Aponte,Elijah Dabod,John C. Reeder,Peter Siba,Peter A. Zimmerman,Timothy M. E. Davis,Christopher L. King,Christopher L. King,Pascal Michon,Ivo Mueller +19 more
TL;DR: The association of Southeast Asian ovalocytosis with Plasmodium vivax infection by genotyping 1975 children enrolled in three independent epidemiological studies conducted in the Madang area of Papua New Guinea and assessing P. v Vivax infection and disease in the children.
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Diagnosing infection levels of four human malaria parasite species by a polymerase chain reaction/ligase detection reaction fluorescent microsphere-based assay
David T. McNamara,Laurin J. Kasehagen,Brian T. Grimberg,Jennifer L. Cole-Tobian,William E. Collins,Peter A. Zimmerman +5 more
TL;DR: This assay, which uses Luminex FlexMAP microspheres, provides simultaneous, semi-quantitative detection of infection by all four human malaria parasite species at a sensitivity and specificity equal to other PCR-based assays.
Journal ArticleDOI
Fy(a)/Fy(b) antigen polymorphism in human erythrocyte Duffy antigen affects susceptibility to Plasmodium vivax malaria.
Christopher L. King,John H. Adams,Jia Xianli,Brian T. Grimberg,Amy M. McHenry,Lior J. Greenberg,Asim A. Siddiqui,Rosalind E. Howes,Mônica da Silva-Nunes,Marcelo U. Ferreira,Peter A. Zimmerman +10 more
TL;DR: It is shown that Fya, compared with Fyb, significantly diminishes binding of Pv Duffy binding protein (PvDBP) at the erythrocyte surface, and is associated with a reduced risk of clinical Pv in humans, and that efficacy of a PvDBP-based vaccine may differ among populations with different Fy phenotypes.