There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality.

Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

I and i

Improved optimization for the robust and accurate linear registration and motion correction of brain images

http://repositorium.sdum.uminho.pt/bitstream/1822/48763/1/1-s2.0-S037026931200857X-main.pdf

Observation of a new particle in the search for the Standard Model Higgs boson with the ATLAS detector at the LHC

This paper surveys the field of augmented reality AR, in which 3D virtual objects are integrated into a 3D real environment in real time. It describes the medical, manufacturing, visualization, path planning, entertainment, and military applications that have been explored. This paper describes the characteristics of augmented reality systems, including a detailed discussion of the tradeoffs between optical and video blending approaches. Registration and sensing errors are two of the biggest problems in building effective augmented reality systems, so this paper summarizes current efforts to overcome these problems. Future directions and areas requiring further research are discussed. This survey provides a starting point for anyone interested in researching or using augmented reality.

/pdf/a-survey-of-augmented-reality-17irtaxt7z.pdf

A survey of augmented reality

http://library.utia.cas.cz/prace/20030125.pdf

Image registration methods: a survey

https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/trc2.12235

The long‐term impact of loneliness and social isolation on depression and anxiety in memory clinic attendees and their care partners: A longitudinal actor–partner interdependence model

Our goal was to assess the enrichment utility of hippocampal volume (HV) as an enrichment biomarker in amnestic mild cognitive impairment (aMCI) clinical trials, and, hence, develop an HV neuroimaging-informed clinical trial enrichment tool. Modeling of integrated longitudinal patient-level data came from open-access natural history studies in patients diagnosed with aMCI-the Alzheimer's Disease Neuroimaging Initiative (ADNI)-1 and ADNI-2-and indicated that a decrease of 1 cm3 with respect to the analysis dataset median baseline intracranial volume-adjusted HV (ICV-HV; ~ 5 cm3 ) is associated with > 50% increase in disease progression rate as measured by the Clinical Dementia Rating Scale-Sum of Boxes. Clinical trial simulations showed that the inclusion of aMCI subjects with baseline ICV-HV below the 84th or 50th percentile allowed an approximate reduction in trial size of at least 26% and 55%, respectively. This clinical trial enrichment tool can help design more efficient and informative clinical trials.

Hippocampal neuroimaging-informed clinical trial enrichment tool for amnestic mild cognitive impairment using open data.

The goal of this work is to evaluate Voxel-Based Morphometry and three longitudinally-tailored methods
of VBM.We use a cohort of simulated images produced by deforming original scans using a Finite Element Method,
guided to emulate Alzheimer-like changes. The simulated images provide quite realistic data with a known pattern of
spatial atrophy, with which VBM’s findings can be meaningfully compared. We believe this is the first evaluation of VBM for which anatomically-plausible ‘gold-standard’ results are available. The three longitudinal VBM methods
have been implemented within the unified segmentation framework of SPM5; one of the techniques is a newly
developed procedure, which shows promising potential.

/pdf/longitudinal-voxel-based-morphometry-with-unified-lzc38isj69.pdf

Longitudinal Voxel-based morphometry with unified segmentation: evaluation on simulated Alzheimer’s disease

Deformation based morphometry is used to detect differences in in-vivo Magnetic Resonance Image (MRI) of the mouse brain obtained from two transgenic strains: TASTPM mice that over-express proteins associated with Alzheimer's disease, and wild-type mice MRI was carried out at four time points We compare two different methods to detect group differences in the longitudinal and cross-sectional data Both methods are based on non-rigid registration of the images to a mouse brain atlas The whole brain volume measurements on 27 TASTPM and wild-type animals are reproducible to within 04% of whole brain volume The agreement between different methods for measuring volumes in a serial study is shown The ability to quantify changes in growth between strains in whole brain, hippocampus and cerebral cortex is demonstrated

Derek L. G. Hill

Papers

The long‐term impact of loneliness and social isolation on depression and anxiety in memory clinic attendees and their care partners: A longitudinal actor–partner interdependence model

Hippocampal neuroimaging-informed clinical trial enrichment tool for amnestic mild cognitive impairment using open data.

Longitudinal Voxel-based morphometry with unified segmentation: evaluation on simulated Alzheimer’s disease

Deformation based morphometry analysis of serial magnetic resonance images of mouse brains

Preparation and Display of Image Data