Klaus Romero

TL;DR: Contrary to long-standing views, men and women with the APOE &egr;3/&egR;4 genotype have nearly the same odds of developing AD from age 55 to 85 years, but women have an increased risk at younger ages.

TL;DR: TKV was the most important prognostic term for 30% decline in eG FR in autosomal dominant polycystic kidney disease patients with and without preserved baseline eGFR and was formally qualified as a prognostic enrichment biomarker for selecting patients at high risk for a progressive decline in renal function for inclusion in interventional clinical trials.

TL;DR: An adequate BR meta-analysis model for ADAS-cog using both summary-level and patient-level data was developed, allowing for simultaneous fitting of summary and patient level data, and constrains values to the range of the original instrument for simulation purposes.

TL;DR: The HFS-TB model is highly accurate at forecasting optimal drug exposures, doses, and dosing schedules for use in the clinic, and the forecasting accuracy of a completely unreliable tool was also calculated.

TL;DR: There is a need for formal quantitative analyses of how well DDTs forecast clinical outcomes, and no single nonclinical in vitro or animal model recapitulates all aspects of human tuberculosis.