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Derek L. Stirewalt
Researcher at Fred Hutchinson Cancer Research Center
Publications - 112
Citations - 17324
Derek L. Stirewalt is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Leukemia & Myeloid leukemia. The author has an hindex of 42, co-authored 101 publications receiving 15718 citations. Previous affiliations of Derek L. Stirewalt include University of Washington Medical Center & University of Washington.
Papers
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Journal ArticleDOI
FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia.
Derek L. Stirewalt,Kenneth J. Kopecky,Soheil Meshinchi,Frederick R. Appelbaum,Marilyn L. Slovak,Cheryl L. Willman,Jerald P. Radich +6 more
TL;DR: Results indicate that mutations in FLT3, RAS, or TP53 are common in older patients with AML and are associated with specific AML phenotypes as defined by laboratory values, cytogenetics, and clinical outcomes.
Journal ArticleDOI
Clinical implications of FLT3 mutations in pediatric AML
Soheil Meshinchi,Todd A. Alonzo,Derek L. Stirewalt,Michel Zwaan,Martin Zimmerman,Dirk Reinhardt,Gertjan J.L. Kaspers,Nyla A. Heerema,Robert B. Gerbing,Beverly J. Lange,Jerald P. Radich +10 more
TL;DR: FLT3 mutation status of 630 children with de novo acute myeloid leukemia (AML) treated on CCG-2941 and -2961 was determined, and ITD-AR was calculated for patients with FLT3/ITD, which defines the prognostic significance in FLT 3/ITd-positive AML.
Journal ArticleDOI
Size of FLT3 internal tandem duplication has prognostic significance in patients with acute myeloid leukemia.
Derek L. Stirewalt,Kenneth J. Kopecky,Soheil Meshinchi,Julia H. Engel,Era L. Pogosova-Agadjanyan,Jeremy W. Linsley,Marilyn L. Slovak,Cheryl L. Willman,Jerald P. Radich +8 more
TL;DR: Two studies suggest that ITD size may have prognostic significance in acute myeloid leukemia patients enrolled in Southwest Oncology Group studies.
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Prevalence and prognostic implications of CEBPA mutations in pediatric acute myeloid leukemia (AML): a report from the Children's Oncology Group.
Phoenix A. Ho,Phoenix A. Ho,Todd A. Alonzo,Todd A. Alonzo,Robert B. Gerbing,Jessica A. Pollard,Jessica A. Pollard,Jessica A. Pollard,Derek L. Stirewalt,Craig A. Hurwitz,Nyla A. Heerema,Betsy A. Hirsch,Susana C. Raimondi,Beverly J. Lange,Janet Franklin,Jerald P. Radich,Soheil Meshinchi,Soheil Meshinchi +17 more
TL;DR: As CEBPA mutations are associated with lower relapse rate and improved survival,CEBPA mutation analysis needs to be incorporated into initial screening for risk identification and therapy allocation at diagnosis.
Journal ArticleDOI
Gene expression profiling of adult acute myeloid leukemia identifies novel biologic clusters for risk classification and outcome prediction
Carla S. Wilson,George S. Davidson,Shawn Martin,Erik Andries,Jeffrey W. Potter,Richard C. Harvey,Kerem Ar,Yuexian Xu,Kenneth J. Kopecky,Donna P. Ankerst,Holly Gundacker,Marilyn L. Slovak,Monica P. Mosquera-Caro,I-Ming Chen,Derek L. Stirewalt,Maurice H. Murphy,Frederick A. Schultz,Huining Kang,Xuefei Wang,Jerald P. Radich,Frederick R. Appelbaum,Susan R. Atlas,John E. Godwin,Cheryl L. Willman +23 more
TL;DR: Gen expression profiles obtained in pretreatment leukemic samples from 170 patients provide insights into novel groups of AML not predicted by traditional studies that impact prognosis and potential therapy.