D
Derek P. Chew
Researcher at Flinders University
Publications - 393
Citations - 21169
Derek P. Chew is an academic researcher from Flinders University. The author has contributed to research in topics: Myocardial infarction & Acute coronary syndrome. The author has an hindex of 60, co-authored 342 publications receiving 18879 citations. Previous affiliations of Derek P. Chew include Flinders Medical Centre & Auckland City Hospital.
Papers
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Journal ArticleDOI
Defining the Optimal Activated Clotting Time During Percutaneous Coronary Intervention: Aggregate Results From 6 Randomized, Controlled Trials
Derek P. Chew,Deepak L. Bhatt,A. Michael Lincoff,David J. Moliterno,Sorin J. Brener,Katherine E. Wolski,Eric J. Topol +6 more
TL;DR: In this paper, the optimal suppression of ischemic events with unfractionated heparin therapy in patients undergoing percutaneous coronary intervention demands treatment to ACT levels that are substantially higher than currently appreciated.
Journal ArticleDOI
Death Following Creatine Kinase-MB Elevation After Coronary Intervention Identification of an Early Risk Period: Importance of Creatine Kinase-MB Level, Completeness of Revascularization, Ventricular Function, and Probable Benefit of Statin Therapy
Stephen G. Ellis,Derek P. Chew,Albert W. Chan,Patrick L. Whitlow,Jakob P. Schneider,Eric J. Topol +5 more
TL;DR: Patients with CK-MB elevation after PCI are at excess risk of death for 3 to 4 months, although prolonging hospitalization for CK- MB 1 to 5× is unlikely to modify risk, and several factors suggest that inflammation may play a part in the excessrisk of death.
Journal ArticleDOI
Comparison of bivalirudin versus heparin during percutaneous coronary intervention (the Randomized Evaluation of PCI Linking Angiomax to Reduced Clinical Events [REPLACE]-1 trial).
A. Michael Lincoff,John A. Bittl,Neal S. Kleiman,Ian J. Sarembock,J. Daniel Jackman,Sameer Mehta,Mark A. Tannenbaum,Alan Niederman,William Bachinsky,J Tift-Mann,H Graham Parker,Dean J. Kereiakes,Robert A. Harrington,Frederick Feit,Elizabeth S. Maierson,Derek P. Chew,Eric J. Topol +16 more
TL;DR: This trial represents the largest prospective dataset of bivalirudin administered concomitantly with planned GP IIb/IIIa blockade and provides evidence of the safety and efficacy of this combined antithrombotic approach.
Journal ArticleDOI
National Heart Foundation of Australia & Cardiac Society of Australia and New Zealand: Australian Clinical Guidelines for the Management of Acute Coronary Syndromes 2016.
Derek P. Chew,Ian A Scott,Louise Cullen,John K. French,Tom Briffa,Philip A. Tideman,Stephen Woodruffe,A. R. Kerr,Maree Branagan,Philip E. Aylward +9 more
TL;DR: The process of Developing the 2016 ACS Guidelines and the development of Recommendations are outlined, as well as some of the specific questions asked, are described.
Journal ArticleDOI
Relation of inflammation and benefit of statins after percutaneous coronary interventions.
Albert W. Chan,Deepak L. Bhatt,Derek P. Chew,Joel P. Reginelli,Jakob P. Schneider,Eric J. Topol,Stephen G. Ellis +6 more
TL;DR: Statin therapy before PCI is associated with a marked reduction in mortality among patients with high hsCRP levels and an improved targeting of statin therapy and clinical outcome among patients undergoing PCI is recommended.