Derek S. Sim

TL;DR: Novel instrumentation using confocal and widefield microscopy to image and analyze thrombus formation in real time in the microcirculation of a living mouse and to analyze the effect of antithrombotic agents in vivo is developed.

TL;DR: It is demonstrated that cAMP in circulating platelets controls attachment to and detachment from sites of arteriolar injury, and the status of the intracellular signaling machinery prior to engagement of platelet receptors influences the rate of platelets accumulation during thrombus formation.

TL;DR: It is demonstrated that Syk inhibition ameliorates both the acute and chronic responses to vascular injury without affecting hemostasis, and may be exemplary of a new class of antiatherothrombotic agents that target the interface between thrombosis and inflammation.

TL;DR: Results indicate a role for helix 8 in conferring sensitivity to small molecules, and show that this sensitivity can be exploited to control platelet activation during thrombus formation.

TL;DR: The role of platelet intracellular signaling, P‐selectin expression on platelets, and tissue factor‐bearing microparticles in thrombus formation is discussed.