Showing papers in "Journal of Thrombosis and Haemostasis in 2003"

TL;DR: It is suspicion that the performance of the entire process of thrombin generation from initiation through propagation and termination phases of the reaction are relevant with respect to both hemorrhagic and thrombotic pathology.

TL;DR: The mechanism of interaction between the VWF A1 domain and glycoprotein Ibα has been elucidated in detail, bringing us closer to understanding how this adhesive bond can oppose the fluid dynamic effects of rapidly flowing blood contributing to platelet adhesion and activation.

TL;DR: A review of the interactions between inflammation and coagulation and inflammatory mediators will summarize the insights into the evolution and linkages that have become evident from recent structural studies.

TL;DR: The hemostasis laboratory offers the most appropriate tools for the assessment of the in vivo significance of microparticles, since they are thought to reflect a balance between cell stimulation, proliferation, and death and it is conceivable that they are discerned as sensors for the maintenance of homeostasis in multicellular organisms.

TL;DR: This review will discuss the major platelet adhesive interactions regulating platelet thrombus formation under high shear, with specific focus on the VWF and collagen receptors and the signaling mechanisms utilized by these receptors to induce platelet activation.

TL;DR: Preclinical studies show proof‐of‐principle that PlGF and VEGFR‐1 are promising therapeutic targets to treat angiogenesis and inflammation related disorders and whether this is also true for patients.

TL;DR: Data suggest that the whole blood coagulation TEG profile, following activation with minute amounts of TF, may reflect the hemostatic potential in patients suspected of impaired hemostasis.

TL;DR: The clustering of inflammation, adipose tissue accumulation and insulin resistance suggests an etiopathological link and proinflammatory cytokines might regulate PAI‐1 expression in IRS; however, more studies are needed to confirm this complex mechanism in humans.

TL;DR: Human cell‐derived microparticles promote thrombus formation in vivo in a TF‐dependent manner and might be the direct cause of an increased thromboembolic tendency in various patient groups.

TL;DR: The evolutionary paths, traditional roles, and previously unrecognized biological capacities of platelets that interface thrombosis with inflammation are reviewed and new roles in inflammatory diseases are identified.

TL;DR: In this review, a summary of the molecular mechanisms of nitric oxides actions in vascular biology and pathology is summarized.

TL;DR: Once a clinical diagnosis of HIT is made, heparin should be ceased immediately and treatment with an alternative anticoagulant (such as danaparoid, r‐hirudin or argatroban) commenced, unless the diagnosis is subsequently proven to be incorrect.

TL;DR: The synthetic analog of vasopressin desmopressin (DDAVP) is widely used for the treatment of patients with von Willebrand disease, hemophilia A, several platelet disorders, and uremic bleeding.

TL;DR: In patients undergoing total hip or knee replacement, preoperatively initiated s.c. melagatran followed by oral ximelag atran was significantly more effective in preventing VTE than preoperative initiated s-c.

TL;DR: Protease receptors are major determinants of the biological outcome of coagulation factor signaling on vascular cells, and are now recognized as an important aspect of the pro‐ and anti‐coagulant pathways.

TL;DR: A benefit was found in patients with a poor prognosis for a live birth (five or more miscarriages), where the live birth rate was increased from 18.2% to 61.6% and the benefit was not statistically significant, probably due to the small number of patients.

TL;DR: The incidence of inhibitors in the MHA population was 7.4%.

TL;DR: Multimeric analysis indicated that the rate of VWF proteolysis differed between blood groups and was greater for group O VWF than for non‐O VWF in the rank order O’≥ B’s> A’A”≤ AB, and measurement of the collagen binding activity ofVWF of each blood group following proteolytic activity corroborated the results obtained on multimer analysis.

TL;DR: The risk of arterial disease in oral contraceptive users and users of hormone replacement therapy is at most weakly affected by the presence of prothrombotic abnormalities.

TL;DR: Activation of the coagulation and fibrinolytic cascades in the joint and in the circulation is evident in both inflammatory and degenerative joint diseases.

TL;DR: A review of the emerging appreciation of the cellular and molecular basis of thrombopoiesis can be found in this paper, where the experimental findings forge stronger links between cellular processes and molecular mechanisms, while observation of the underlying morphologic events in beginning to yield insights into the cytoskeletal mechanics of proplatelet formation.

TL;DR: It is concluded that the prevalence of platelet function defects and other inherited bleeding disorders is substantial in a multiracial US population of women with unexplained menorrhagia.

TL;DR: Oral ximelagatran appears to be a promising alternative to current anticoagulant therapy to limit the progression of acute DVT, and it seems to possess a wide therapeutic window.

TL;DR: It is demonstrated that the B MP‐2/MGP complex exists in vivo, consistent with a role for MGP as a BMP‐2 inhibitor.

TL;DR: Properly designed clinical trials are urgently required in children with systemic VTE/PE and CSVT to define the best methods of diagnosis, treatment and long‐term management.

TL;DR: It is indicated that inherited prothrombotic coagulation proteins do not contribute significantly to the pathogenesis of VTEs in neonates and children, in whom the most significant etiological factors are the presence of a CVL and/or other medical conditions.

TL;DR: The mechanisms that regulate endothelial cell migration, smooth muscle cell activation, and extracellular matrix protein production are described, all of which are key components in the inflammatory response to vascular injury.

TL;DR: It was found that clinical characteristics of VTE patients differed across race groups, and the need to determine gene polymorphisms associated with VTE in African‐Americans was underscore.