D
Derrick S. Grant
Researcher at Thomas Jefferson University
Publications - 52
Citations - 6491
Derrick S. Grant is an academic researcher from Thomas Jefferson University. The author has contributed to research in topics: Angiogenesis & Endothelial stem cell. The author has an hindex of 32, co-authored 52 publications receiving 6388 citations. Previous affiliations of Derrick S. Grant include Children's National Medical Center & National Institutes of Health.
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Journal ArticleDOI
Two different laminin domains mediate the differentiation of human endothelial cells into capillary-like structures in vitro
Derrick S. Grant,Ken-ichiro Tashiro,Bartolome Segui-Real,Yoshihiko Yamada,George R. Martin,Hynda K. Kleinman +5 more
TL;DR: It is shown that the laminin-derived synthetic peptide YIGSR contains sufficient information to induce single endothelial cells to form ring-like structures surrounding a hollow lumen, the basic putative unit in the formation of capillaries.
Journal ArticleDOI
Scatter factor induces blood vessel formation in vivo.
Derrick S. Grant,Hynda K. Kleinman,Itzhak D. Goldberg,Mahdu M. Bhargava,Brian J. Nickoloff,James L. Kinsella,Peter J. Polverini,Eliot M. Rosen +7 more
TL;DR: Using two different in vivo assays, it is shown that physiologic quantities of purified native mouse scatter factor and recombinant human hepatocyte growth factor induce angiogenesis (the formation of new blood vessels) and that immunoreactive scatter factor is present surrounding sites of blood vessel formation in psoriatic skin.
Scatter factor induces blood vessel formation in vivo (hepatocyte growth factor/angiogenesis/endothelium/psoriasis/plasninogen activator)
Derrick S. Grant,Hynda K. Kleinman,Itzhak D. GOLDBERGt,Mahdu M. BHARGAVAt,J Brian,James L. Kinsella,Peter J. Polverini,Eliot M. Roseni +7 more
TL;DR: This article showed that scatter factor may act as a paracrine mediator in pathologic angio- genesis associated with human inflammatory disease, and immunoreactive scatter factor is present surrounding sites of blood vessel formation in psoriatic skin.
Journal ArticleDOI
Neuropeptide Y: a novel angiogenic factor from the sympathetic nerves and endothelium.
Zofia Zukowska-Grojec,Ewa Karwatowska-Prokopczuk,Wesley Rose,Janice Rone,Sharareh Movafagh,Hong Ji,Yunyun Yeh,Wen-Tien Chen,Hynda K. Kleinman,Eric Grouzmann,Derrick S. Grant +10 more
TL;DR: Endothelium is the site of action of NPY but also the origin of the autocrine NPY system, which, together with the sympathetic nerves, may be important in angiogenesis during tissue development and repair.
Journal ArticleDOI
Type IV collagenase(s) and TIMPs modulate endothelial cell morphogenesis in vitro
H. William Schnaper,H. William Schnaper,Derrick S. Grant,William G. Stetler-Stevenson,Rafael Fridman,Gabriella D'Orazi,Anne N. Murphy,Robert E. Bird,Matti Hoythya,Thomas R. Fuerst,Deborah L. French,James P. Quigley,Hynda K. Kleinman +12 more
TL;DR: It is demonstrated that gelatinase/type IV collagenase activity is important in endothelial cell morphogenesis on Matrigel, and a role for collagenases in formation of new capillaries in vivo is suggested.