Showing papers in "Cell in 1989"

TL;DR: The location, orientation, and structure of the hormone regulatory elements (HRE) in nine hormonally modulated genes is described and a model for the interaction is proposed in which a dimer of the receptor in head-to-head orientation binds to the inverted symmetry element of the HRE.

TL;DR: Results suggest that phosphorylation of CREB may stimulate transcription by a mechanism other than by simply providing negative charge, as CREB mutants containing acidic residues in place of the Ser-133 phosphoacceptor were also transcriptionally inactive.

TL;DR: In this paper, two cDNAs were isolated whose dimerized products bind specifically to a DNA sequence, kappa E2, located in the immunoglobulin kappa chain enhancer.

TL;DR: DNA clones of the wild-type p53 proto-oncogene inhibit the ability of E1Aplus ras or mutant p53 plus ras-activated oncogenes to transform primary rat embryo fibroblasts, suggesting that the p53 prototype can act negatively to block transformation.

TL;DR: A previously undescribed adhesion molecule, VCAM-1, which is induced by cytokines on human endothelial cells and binds lymphocytes is cloned using a novel method requiring neither monoclonal antibodies nor purified protein.

TL;DR: It is shown that all ras proteins are polyisoprenylated on their C-terminal cysteine (Cys186) and palmitoylation increases the avidity of this binding and enhances their transforming activity.

TL;DR: The HLH domain can mediate heterodimer formation between either daughterless, E12, or E47 and achaete-scute T3 or MyoD to form proteins with high affinity for the kappa E2 site in the immunoglobulin kappa chain enhancer.

TL;DR: It is suggested that BFA disrupts a dynamic membrane-recycling pathway between the ER and cis/medial Golgi, effectively blocking membrane transport out of but not back to the ER.

TL;DR: Northern analysis of strains containing plasmid inserts with various promoter mutations suggests that the stimulation in recombination is mediated by events initiating within the integrated plasmID sequences.

TL;DR: The identification of telomerase in HeLa cells with only approximately 100 telomeres indicates that telomersase-mediated telomere maintenance is conserved throughout eukaryotes.

TL;DR: Comment intervient le NF-kB, quels sont les systemes dans lesquels il joue un role, tels que les messages intracellulaires, l'activation des cellules C, the regulation of the cytokinine, ou encore l'utilisation par les virus

TL;DR: The Inr constitutes the simplest functional promoter that has been identified and provides one explanation for how promoters that lack TATA elements direct transcription initiation.

TL;DR: It is reported that an 80 kd single polypeptide chain (IL-6-R) is involved in IL-6 binding and that IL- 6 triggers the association of this receptor with a non-ligand-binding membrane glycoprotein, gp130, extracellularly and can provide the IL-7 signal.

TL;DR: Using 3H-thymidine labeling, a subpopulation of corneal epithelial basal cells are identified in the peripheral cornea in a region called limbus that are normally slow cycling, but can be stimulated to proliferate in response to wounding and to a tumor promotor, TPA.

TL;DR: In this article, minigene constructs representing the bcl-2-Ig fusion gene found at this chromosomal breakpoint were placed into the germ line of mice to assess the effects of the t(14;18) interchromosomal translocation during development.

TL;DR: To study the putative precursor proteins of Alzheimer's disease A4 amyloid protein, polyclonal and monoclonal antibodies were raised against a recombinant bacterial PreA4(695) fusion protein to identify the precursors in different cell lines as well as in human brain homogenates and cerebrospinal fluid.

TL;DR: It is proposed that TNF released from macrophages in the microenvironment of developing granulomas is involved in a process of autoamplification: acting in an autocrine or paracrine way, it enhances its own synthesis and release, thus favoring further macrophage accumulation and differentiation leading to bacterial elimination.

TL;DR: The isolation, sequence, and initial characterization of the cDNA for the muscle-specific regulatory factor skeletal myogenin are described, and together with myd may constitute a set of factors that interact to regulate the determination and differentiation of muscle cells.

TL;DR: The major human rhinovirus receptor has been identified with monoclonal antibodies that inhibit rhInovirus infection and protein sequence from the 95 kd protein showed an identity with that of intercellular adhesion molecule-1 (ICAM-1).

TL;DR: The RAG-1 (recombination activating gene-1) genomic locus, which activates V(D)J recombination when introduced into NIH 3T3 fibroblasts, was isolated by serial genomic transfections of oligonucleotide-tagged DNA.

TL;DR: It is proposed that the G-quartet structure must be dealt with in vivo by the telomere replication machinery, hydrogen-bonded structures formed from four guanosine residues in a square-planar array.

TL;DR: These unexpected results suggest a role for these major nucleolar proteins in the nucleocytoplasmic transport of ribosomal components and suggest that transient exposure of shuttling proteins to the cy toplasm may provide a mechanism for cytop lasmic regulation of nuclear activities.

TL;DR: It is shown that, for mice, the protein in association with major histocompatibility complex class II molecules stimulates virtually all T cells bearing V beta 3 and V beta 8.3, and few others, demonstrating that tolerance to exogenously administered antigen can be caused by clonal deletion of reactive T cells.

TL;DR: Northern hybridization analysis indicates that poliov virus receptor transcripts are expressed in a wide range of human tissues, in contrast to the limited expression of virus binding sites, which suggests that additional factors or modifications of the receptor protein are required to permit poliovirus attachment.

TL;DR: It is shown that the N-terminal A/B region of the ER contains an independent constitutive activation function (TAF-1) that exhibits cell type specificity since it activates transcription efficiently in chicken embryo fibroblasts, but only poorly in HeLa cells.

TL;DR: In this paper, the authors look for changes in p105-RB that may regulate its activity during the cell cycle, and generate synchronized cell populations and follow their progression through the cell-cycle.

TL;DR: Lithium, with an atomic weight of 6.9, is the smallest of the alkali metals, yet this simple ion can exert a profound effect on both human behavior and early embryonic devel- opment.

TL;DR: It is demonstrated here that CEA mediates Ca2+-independent, homotypic aggregation of cultured human colon adenocarcinoma cells (LS-180) and rodent cells transfected with functional CEA cDNA and can be considered a new addition to the family of intercellular adhesion molecules.

TL;DR: The Krev-1 gene seems to play an important role(s) in a wide variety of tissues, and may be involved in the negative growth regulation of certain cell types.

TL;DR: Alignment shows a clear relationship among genes in the mouse and Drosophila complexes, based on relative position, sequence identity, and domains of expression along the rostral-caudal axis.