Desmond J. Oathes

TL;DR: A concordance is identified in terms of integrity of an anterior insula/dorsal anterior cingulate-based network, which may relate to executive function deficits observed across diagnoses, which provides an organizing model that emphasizes the importance of shared neural substrates across psychopathology.

TL;DR: A direct test of the causal mechanisms by combining transcranial magnetic stimulation with functional MRI to causally excite or inhibit TMS-accessible prefrontal nodes within the CEN or SN and determine consequent effects on the DMN found that the default mode network is under inhibitory control specifically from a node in the central executive network, which provides mechanistic insights into prior work that implicates these networks in a range of neuropsychiatric disorders.

TL;DR: Findings of heightened and indiscriminate amygdala responses to anticipatory signals in generalized anxiety disorder and of anterior cingulate cortex associations with treatment response provide neurobiological support for the role of anticipatory processes in the pathophysiology of generalized anxiety Disorder.

TL;DR: Lower mean fractional anisotropy values in the bilateral uncinate fasciculus indicated reduced frontolimbic structural connectivity in patients with GAD, suggesting a neural basis for emotion regulation deficits in GAD.

TL;DR: Using resting-state functional magnetic resonance imaging, data show that a single conceptual model alone provides an incomplete mapping of psychopathology to neurobiology, and the data support an additive model that best captures abnormal neural patterns in patients with anxiety and depression.