D
Dhandapani Kuppuswamy
Researcher at Medical University of South Carolina
Publications - 41
Citations - 1921
Dhandapani Kuppuswamy is an academic researcher from Medical University of South Carolina. The author has contributed to research in topics: Pressure overload & Integrin. The author has an hindex of 26, co-authored 40 publications receiving 1720 citations. Previous affiliations of Dhandapani Kuppuswamy include United States Department of Veterans Affairs & Sewanee: The University of the South.
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Journal ArticleDOI
c-Raf/MEK/ERK pathway controls protein kinase C-mediated p70S6K activation in adult cardiac muscle cells
Yoshihiro Iijima,Martin Laser,Hirokazu Shiraishi,Christopher D. Willey,Balasubramanian Sundaravadivel,Lin Xu,Paul J. McDermott,Paul J. McDermott,Dhandapani Kuppuswamy,Dhandapani Kuppuswamy +9 more
TL;DR: In vivo and in vitro studies indicate that the PKC/c-Raf/MEK/ERK pathway plays a major role in the S6K1 activation in hypertrophic cardiac growth.
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Association of tyrosine-phosphorylated c-src with the cytoskeleton of hypertrophying myocardium
Dhandapani Kuppuswamy,Charlene M. Kerr,Takahiro Narishige,Vijaykumar S. Kasi,Donald R. Menick,George Cooper +5 more
TL;DR: These studies strongly suggest that non-receptor tyrosine kinases, in particular c-Src, may play a critical role in hypertrophic growth regulation by their association with cytoskeletal structures, possibly via load activation of integrin-mediated signaling.
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Integrin activation and focal complex formation in cardiac hypertrophy.
Martin Laser,Christopher D. Willey,Wenjing Jiang,George Cooper,Donald R. Menick,Michael R. Zile,Dhandapani Kuppuswamy +6 more
TL;DR: This study suggests that multiple signaling pathways originate in pressure-overloaded heart following integrin engagement with ECM proteins, including focal complex formation and ERK1/2 activation, and many of these pathways can be activated in cardiomyocytes via RGD-stimulated integrin activation.
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Graphene Oxide—A Tool for the Preparation of Chemically Crosslinking Free Alginate–Chitosan–Collagen Scaffolds for Bone Tissue Engineering
Elayaraja Kolanthai,Pugazhendhi Abinaya Sindu,Deepak Kumar Khajuria,Sarath Chandra Veerla,Dhandapani Kuppuswamy,Luiz Henrique Catalani,D. Roy Mahapatra +6 more
TL;DR: The potential use of GO to prepare free SA-CS-Col scaffolds with preserved porous structure with elongated Col fibrils is indicated and these composites, which are biocompatible and stable in a biological medium, could be used for application in engineering bone tissues.
Journal ArticleDOI
Microtubule Stabilization in Pressure Overload Cardiac Hypertrophy
Hiroshi Sato,Toshio Nagai,Dhandapani Kuppuswamy,Takahiro Narishige,Masaaki Koide,Donald R. Menick,George Cooper +6 more
TL;DR: Microtubule stabilization, likely facilitated by binding of a microtubule-associated protein, may be a mechanism for the increased microtubules density characteristic of pressure overload cardiac hypertrophy.