Di-Wei Zheng

TL;DR: In vitro study showed that PCCN could increase the intracellular O2 concentration and improve the reactive oxygen species generation in both hypoxic and normoxic environments upon light irradiation, and in vivo experiments indicated that P CCN had superior ability to overcome tumor hypoxia.

TL;DR: MNP@DOX@CCCM nanovehicle showed strong potency for tumor treatment in vivo and the MR imaging and shows great potential for precise therapy/diagnosis of various tumors merely by adjusting the cell membrane source accordingly on the nanoparticle surface.

TL;DR: MON encapsulated with p53 plasmid (MON-p53) was designed to eradicate cancer cells via ferroptosis/apoptosis hybrid pathway by harnessing the recently discovered oxidative stress regulation ability of p53 and the Fenton reaction inducing capability of metal-organic network.

TL;DR: A chimeric peptide, PpIX-1MT, is synthesized, which integrates photosensitizer Ppix with immune checkpoint inhibitor 1MT via a caspase-responsive peptide sequence, Asp-Glu-Val-Asp (DEVD), to realize a cascaded synergistic effect that could inhibit both primary and lung metastasis tumor effectively.

TL;DR: Dextran nanoparticles loaded with a chemotherapeutic agent and bound to phages that eliminate a pro-tumoural gut bacterium and promote the growth of anticancer-compound-producing bacteria boost chemotherapy responses in mouse models of colorectal cancer.