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Xue Dong
Researcher at Wuhan University
Publications - 17
Citations - 657
Xue Dong is an academic researcher from Wuhan University. The author has contributed to research in topics: Immunotherapy & Medicine. The author has an hindex of 8, co-authored 9 publications receiving 276 citations.
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Journal ArticleDOI
Phage-guided modulation of the gut microbiota of mouse models of colorectal cancer augments their responses to chemotherapy.
TL;DR: Dextran nanoparticles loaded with a chemotherapeutic agent and bound to phages that eliminate a pro-tumoural gut bacterium and promote the growth of anticancer-compound-producing bacteria boost chemotherapy responses in mouse models of colorectal cancer.
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Artificially Reprogrammed Macrophages as Tumor-Tropic Immunosuppression-Resistant Biologics to Realize Therapeutics Production and Immune Activation.
Chu-Xin Li,Yu Zhang,Xue Dong,Lu Zhang,Miao-Deng Liu,Bin Li,Ming-Kang Zhang,Jun Feng,Xian-Zheng Zhang +8 more
TL;DR: This study shows that engineering nanomaterial‐reprogrammed live cells as therapeutic biologics may be a more preferable option to the commonly used approaches where nanommaterials are administrated to induce bioresponse of certain cells in vivo.
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Bioinorganic hybrid bacteriophage for modulation of intestinal microbiota to remodel tumor-immune microenvironment against colorectal cancer
TL;DR: In vitro and in vivo studies showed that of M13@Ag treatment could scavenge Fn in gut and lead to reduction in MDSC amplification in the tumor site, and significantly prolonged overall mouse survival in the orthotopic CRC model.
Journal ArticleDOI
PD-1 Blockade for Improving the Antitumor Efficiency of Polymer-Doxorubicin Nanoprodrug.
TL;DR: The results suggest that the therapeutic efficiency of HA-Psi-DOX nanoparticles is significantly improved when combined with checkpoint inhibitors anti-PD-1 antibody (α-PD1) due to the neutralization of immunosuppression by blocking the interaction between PD-L1 and PD-1.
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A vaccine-based nanosystem for initiating innate immunity and improving tumor immunotherapy.
Di-Wei Zheng,Fan Gao,Qian Cheng,Peng Bao,Xue Dong,Jin-Xuan Fan,Wen Song,Xuan Zeng,Si-Xue Cheng,Xian-Zheng Zhang +9 more
TL;DR: A vaccine that integrates CD274 siRNA into the L1 protein of human papillomavirus, which cooperates with ICB by activating innate immunity in breast cancer models is generated, which induces high response rates in various genetically modified breast cancers models with different antigen loads.