Introduction to neural networks.

Judith Jacobi, PharmD, FCCM, BCPS; Gilles L. Fraser, PharmD, FCCM; Douglas B. Coursin, MD; Richard R. Riker, MD; Dorrie Fontaine, RN, DNSc, FAAN; Eric T. Wittbrodt, PharmD; Donald B. Chalfin, MD, MS, FCCM; Michael F. Masica, MD, MPH; H. Scott Bjerke, MD; William M. Coplin, MD; David W. Crippen, MD, FCCM; Barry D. Fuchs, MD; Ruth M. Kelleher, RN; Paul E. Marik, MDBCh, FCCM; Stanley A. Nasraway, Jr, MD, FCCM; Michael J. Murray, MD, PhD, FCCM; William T. Peruzzi, MD, FCCM; Philip D. Lumb, MB, BS, FCCM. Developed through the Task Force of the American College of Critical Care Medicine (ACCM) of the Society of Critical Care Medicine (SCCM), in collaboration with the American Society of Health-System Pharmacists (ASHP), and in alliance with the American College of Chest Physicians; and approved by the Board of Regents of ACCM and the Council of SCCM and the ASHP Board of Directors

/pdf/clinical-practice-guidelines-for-the-sustained-use-of-550x8gqibj.pdf

Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult.

Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events.

Background. Adherence is a factor in the outcome of medical treatment, but the strength and moderators of the adherence-outcome association have not been systematically assessed.Objectives. A quantitative review using meta-analysis of three decades of empirical research correlating adherence with ob

Patient Adherence and Medical Treatment Outcomes: A Meta-Analysis

Infection with human immunodeficiency virus type 1 (HIV-1) is frequently complicated in its late stages by the AIDS dementia complex, a neurological syndrome characterized by abnormalities in cognition, motor performance, and behavior. This dementia is due partially or wholly to a direct effect of the virus on the brain rather than to opportunistic infection, but its pathogenesis is not well understood. Productive HIV-1 brain infection is detected only in a subset of patients and is confined largely or exclusively to macrophages, microglia, and derivative multinucleated cells that are formed by virus-induced cell fusion. Absence of cytolytic infection of neurons, oligodentrocytes, and astrocytes has focused attention on the possible role of indirect mechanisms of brain dysfunction related to either virus or cell-coded toxins. Delayed development of the AIDS dementia complex, despite both early exposure of the nervous system to HIV-1 and chronic leptomeningeal infection, indicates that although this virus is "neurotropic," it is relatively nonpathogenic for the brain in the absence of immunosuppression. Within the context of the permissive effect of immunosuppression, genetic changes in HIV-1 may underlie the neuropathological heterogeneity of the AIDS dementia complex and its relatively independent course in relation to the systemic manifestations of AIDS noted in some patients.

https://science.sciencemag.org/content/sci/239/4840/586.full.pdf

The brain in AIDS: central nervous system HIV-1 infection and AIDS dementia complex

Coroners and allegations of lack of care, UK and Hong Kong.

Human organ transplants bill.

KIE: Brahams summarizes a 1989 decision by the New South Wales (Australia) Court of Appeal involving two liability issues: a physician's responsibility to disclose the risks of a proposed procedure to a patient, and a hospital's liability for the actions of a visiting physician using its facilities. In Ellis v. Wallsend District Hospital, a patient sued a surgeon and the hospital at which he performed surgery that left her a quadriplegic. After securing a decision against the physician, she pursued a claim against the hospital where he was allowed to operate on his private patients in return for caring for the facility's public patients without charge. The Court of Appeal ruled that the hospital was not responsible for the actions of an independent specialist working on its premises. Brahams comments on the implications of Ellis for Britain's National Health Service hospitals.

Diana Brahams

Papers

Coroners and allegations of lack of care, UK and Hong Kong.

Human organ transplants bill.

Informed Consent and Hospital's Liability for Honorary Surgeon: An Australian Decision

USSR: Dr Yuri Massover

Drug Licensing Authority's Use of Originator's Confidential Data