Diana M. Monsalve

TL;DR: Convalescent plasma constitutes the first option in the current situation, since it has been successfully used in other coronaviruses outbreaks, and the benefits of PC are expected to be better achieved if used in non-critically hospitalized patients, in the hope of reducing morbidity and mortality.

TL;DR: Studies on the role of autoreactive T-cells that are generated secondary to molecular mimicry, the diversity of the T-cell receptor repertoires of auto-reactiveT-cells, the roles of exposure to cryptic antigens, the generation of autoimmune B-cell responses, the interaction of microbiota and chemical adjuvants with the host immune systems all provide clues in advancing the understanding of the molecular mechanisms involved in the evolving concept of Molecular mimicry.

TL;DR: A scoping review of the relevant immunological findings in COVID-19 as well as the current reports about autoimmune/autoinflammatory conditions associated with the disease are presented.

TL;DR: The concept of " original antigenic sin" was first proposed by Thomas Francis, Jr. in 1960 and has the potential to rewrite what the authors understand about how the immune system responds to infections and its mechanistic implications on how vaccines should be designed.

TL;DR: This review of studies performed seeking to define the role of bystander activation in systemic and organ-specific ADs will discuss the studies performed and cognizant of individual differences between hosts and the variable latency time for clinical expression of disease, all of which have made the understanding of the etiology of loss of immune tolerance difficult and enigmatic.