Diana Priscila Penso Pires

TL;DR: This review highlights advances in techniques used to engineer phages as vehicles for drug delivery and vaccines, as well as for the assembly of new materials, and discusses existing challenges and opportunities.

TL;DR: This is the first review gathering information about all the depolymerases encoded by fully sequenced phages, which can comprise areas as diverse as medical, chemical, or food-processing industry.

TL;DR: In this article, a synthetic-biology strategy to modulate phage host ranges by engineering phage genomes in Saccharomyces cerevisiae was presented, and the synthetic phages achieved efficient killing of their new target bacteria and were used to selectively remove bacteria from multi-species bacterial communities with cocktails based on common viral scaffolds.

TL;DR: The studies involving the use of phages for the treatment or prevention of bacterial biofilms are summarized, highlighting the biofilm features that can be tackled with phages or combined therapy approaches.

TL;DR: Advances in sequencing technologies and synthetic biology are providing new opportunities to explore the use of temperate phages for therapy against bacterial infections, and by doing so can considerably expand the armamentarium against the escalating threat of antibiotic-resistant bacteria.