D
Diana Skujat
Researcher at University of Tübingen
Publications - 2
Citations - 2660
Diana Skujat is an academic researcher from University of Tübingen. The author has contributed to research in topics: Autophagy & PINK1. The author has an hindex of 2, co-authored 2 publications receiving 2352 citations.
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Journal ArticleDOI
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
Sven Geisler,Kira M. Holmström,Diana Skujat,Fabienne C. Fiesel,Oliver Rothfuss,Philipp J. Kahle,Wolfdieter Springer +6 more
TL;DR: Functional links between PINK1, Parkin and the selective autophagy of mitochondria, which is implicated in the pathogenesis of Parkinson's disease, are provided.
Journal ArticleDOI
The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations.
Sven Geisler,Kira M. Holmström,Angela Treis,Diana Skujat,Stephanie Weber,Fabienne C. Fiesel,Philipp J. Kahle,Wolfdieter Springer +7 more
TL;DR: It is shown that whole mitochondria are turned over via macroautophagy, and PD-associated PINK1 mutations abrogate autophagy of impaired mitochondria upstream of Parkin, which may contribute to disease pathogenesis.