D
Diane M. Klotz
Researcher at Tulane University
Publications - 22
Citations - 1646
Diane M. Klotz is an academic researcher from Tulane University. The author has contributed to research in topics: Receptor & Estrogen. The author has an hindex of 15, co-authored 22 publications receiving 1609 citations. Previous affiliations of Diane M. Klotz include National Institutes of Health & University Medical Center New Orleans.
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Journal ArticleDOI
Synergistic Activation of Estrogen Receptor with Combinations of Environmental Chemicals
Steven F. Arnold,Diane M. Klotz,Bridgette M. Collins,Peter M. Vonier,Louis J. Guillette,John A. McLachlan +5 more
TL;DR: Combinations of two weak environmental estrogens were 1000 times as potent in hER-mediated transactivation as any chemical alone, suggesting that the synergistic interaction of chemical mixtures with the estrogen receptor may have profound environmental implications.
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Identification of environmental chemicals with estrogenic activity using a combination of in vitro assays.
Diane M. Klotz,Barbara S. Beckman,Steven M. Hill,John A. McLachlan,Marian R. Walters,Steven F. Arnold +5 more
TL;DR: It is proposed that a combination of in vitro assays can be used in conjunction with whole animal models for a more complete characterization of chemicals with estrogenic activity.
Journal Article
Expression of a constitutively active estrogen receptor variant in the estrogen receptor-negative BT-20 human breast cancer cell line.
TL;DR: The presence of this ER variant in breast tumor cell lines, as well as breast tumor biopsies and uterine tissue, suggests that it is a naturally occurring variant that may arise by alternative splicing, and whose overexpression may be involved in the progression of breast tumors to a hormone-independent state.
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Activation of a uterine insulin-like growth factor I signaling pathway by clinical and environmental estrogens: requirement of estrogen receptor-alpha.
TL;DR: It is demonstrated that several chemicals shown previously to display estrogenic activities also mimic E2 by activating uterine IGF-I signaling, indicating that ERalpha is required for activation of uterines IGF-IR by these diverse chemicals.
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Potency of combined estrogenic pesticides.
Kavita Ramamoorthy,Fen Wang,Ichen Chen,Stephen Safe,John D. Norris,Donald P. McDonnell,Kevin W. Gaido,Wayne P. Bocchinfuso,Kenneth S. Korach,John A. McLachlan,Steven F. Arnold,Diane M. Klotz,Bridgette M. Collins,Peter M. Vonier,Louis J. Guillette +14 more
TL;DR: Brain hemispheres fixed in buffered 10% formalin were fixed overnight with a solution of 1% glutaraldehyde and 1% paraformaldehyde in 0.12 M phosphate buffer to develop any neurological disease.