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Diego A. Rey Serantes
Researcher at National Scientific and Technical Research Council
Publications - 18
Citations - 214
Diego A. Rey Serantes is an academic researcher from National Scientific and Technical Research Council. The author has contributed to research in topics: Medicine & Brucellosis. The author has an hindex of 8, co-authored 11 publications receiving 175 citations. Previous affiliations of Diego A. Rey Serantes include National Institute of Industrial Technology.
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Journal ArticleDOI
Electrochemical magnetic microbeads-based biosensor for point-of-care serodiagnosis of infectious diseases
María Eugenia Cortina,Luciano J. Melli,Mariano Roberti,Mijal Mass,Gloria Longinotti,Salvador Tropea,Paulina Lloret,Diego A. Rey Serantes,Francisco Salomón,Matías Lloret,Ana J. Caillava,Sabrina Restuccia,Jaime Altcheh,Carlos A. Buscaglia,Laura Malatto,Juan E. Ugalde,Liliana Fraigi,Carlos Moina,Gabriel Ybarra,Andres Eduardo Ciocchini,Diego J. Comerci +20 more
TL;DR: For Chagas disease, a more extensive validation of the test was performed showing that the EMBIA platform displayed an excellent diagnostic performance almost indistinguishable from a fluorescent immunomagnetic assay and the conventional ELISA using the same combination of antigens.
Journal ArticleDOI
Development and Validation of a Novel Diagnostic Test for Human Brucellosis Using a Glyco-engineered Antigen Coupled to Magnetic Beads
Andres Eduardo Ciocchini,Diego A. Rey Serantes,Luciano J. Melli,Jeremy A. Iwashkiw,Bettina Deodato,Jorge C. Wallach,Mario F. Feldman,Juan E. Ugalde,Diego J. Comerci +8 more
TL;DR: The results indicate that, using this assay, it is possible to detect infection caused by the three main human brucellosis agents and make it an attractive diagnostic tool for using not only in clinics and Brucellosis reference laboratories but also in locations with limited laboratory infrastructure and/or minimally trained community health workers.
Journal ArticleDOI
BigA is a novel adhesin of Brucella that mediates adhesion to epithelial cells.
Cecilia Czibener,Fernando Merwaiss,Francisco Fernando Guaimas,Mariela Giselda del Giudice,Diego A. Rey Serantes,Juan Manuel Spera,Juan E. Ugalde +6 more
TL;DR: The identification in Brucella abortus of a novel adhesin that harbours a bacterial immunoglobulin‐like domain and it is demonstrated that this protein is involved in the adhesion to polarized epithelial cells such as the Caco‐2 and Madin–Darby canine kidney models targeting the bacteria to the cell–cell interaction membrane.
Journal ArticleDOI
A bacterial engineered glycoprotein as a novel antigen for diagnosis of bovine brucellosis.
Andres Eduardo Ciocchini,Diego A. Rey Serantes,Luciano J. Melli,Leticia Soledad Guidolin,Jeremy A. Iwashkiw,Sebastian Elena,Cristina Franco,Ana M. Nicola,Mario F. Feldman,Diego J. Comerci,Juan E. Ugalde +10 more
TL;DR: The first recombinant glycoprotein antigen, an N-formylperosamine O-polysaccharide-protein conjugate (OAg-AcrA), is validated, suitable for the development of new standard immunological tests for screening and confirmatory diagnosis of bovine brucellosis in regions or countries with bru cellosis-control programs.
Journal ArticleDOI
The Effector Protein BPE005 from Brucella abortus Induces Collagen Deposition and Matrix Metalloproteinase 9 Downmodulation via Transforming Growth Factor β1 in Hepatic Stellate Cells.
Paula Constanza Arriola Benitez,Diego A. Rey Serantes,Claudia Karina Herrmann,Ayelén Ivana Pesce Viglietti,Silvia Vanzulli,Guillermo H. Giambartolomei,Diego J. Comerci,María Victoria Delpino +7 more
TL;DR: Results indicate that B. abortus tilts LX-2 cells to a profibrogenic phenotype employing a functional T4SS and the secreted BPE005 protein through a mechanism that involves the cAMP and PKA signaling pathway.