D
Diego Acosta-Alvear
Researcher at University of California, Santa Barbara
Publications - 41
Citations - 3815
Diego Acosta-Alvear is an academic researcher from University of California, Santa Barbara. The author has contributed to research in topics: Unfolded protein response & Endoplasmic reticulum. The author has an hindex of 21, co-authored 36 publications receiving 3093 citations. Previous affiliations of Diego Acosta-Alvear include Howard Hughes Medical Institute & University of California, San Francisco.
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Journal ArticleDOI
XBP1 Controls Diverse Cell Type- and Condition-Specific Transcriptional Regulatory Networks
Diego Acosta-Alvear,Yiming Zhou,Alexandre Blais,Mary Tsikitis,Nathan H. Lents,Carolina Arias,Christen J. Lennon,Yuval Kluger,Brian David Dynlacht +8 more
TL;DR: A core group of genes involved in constitutive maintenance of ER function in all cell types and tissue- and condition-specific targets are identified and a cadre of unexpected targets that link XBP1 to neurodegenerative and myodegenerative diseases, as well as to DNA damage and repair pathways are identified.
Journal ArticleDOI
Pharmacological brake-release of mRNA translation enhances cognitive memory
Carmela Sidrauski,Diego Acosta-Alvear,Arkady Khoutorsky,Punitha Vedantham,Brian R. Hearn,Han Li,Karine Gamache,Ciara M Gallagher,Kenny K. H. Ang,Christopher W. Wilson,Voytek Okreglak,Avi Ashkenazi,Byron Hann,Karim Nader,Michelle R. Arkin,Adam R. Renslo,Nahum Sonenberg,Peter Walter +17 more
TL;DR: A small molecule is identified, named ISRIB, that potently reverses the effects of eIF2α phosphorylation and promises to contribute to the understanding and treatment of cognitive disorders.
Journal ArticleDOI
Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis.
Min Lu,David A. Lawrence,Scot A. Marsters,Diego Acosta-Alvear,Philipp Kimmig,Aaron S Mendez,Adrienne W. Paton,James C. Paton,Peter Walter,Avi Ashkenazi +9 more
TL;DR: It is reported that unmitigated ER stress promoted apoptosis through cell-autonomous, UPR-controlled activation of death receptor 5 (DR5), which integrates opposing UPR signals to couple ER stress and apoptotic cell fate.
Journal ArticleDOI
An initial blueprint for myogenic differentiation
Alexandre Blais,Mary Tsikitis,Diego Acosta-Alvear,Roded Sharan,Yuval Kluger,Brian David Dynlacht +5 more
TL;DR: It is found that MRFs play an unexpectedly wide-ranging role in directing the assembly and usage of the neuromuscular junction and these factors also prepare myoblasts to respond to diverse types of stress.
Journal ArticleDOI
The Unfolded Protein Response: Detecting and Responding to Fluctuations in the Protein-Folding Capacity of the Endoplasmic Reticulum
TL;DR: Recent developments in the field that have provided new insights into the ER stress-sensing mechanisms used by UPR sensors and the mechanisms by which they integrate various cellular inputs to adjust the folding capacity of the organelle to accommodate to fluctuations in ER protein-folding demands are reviewed.