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Byron Hann
Researcher at University of California, San Francisco
Publications - 102
Citations - 6647
Byron Hann is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Cancer & Kinase. The author has an hindex of 34, co-authored 94 publications receiving 5747 citations. Previous affiliations of Byron Hann include Lawrence Berkeley National Laboratory & University of California.
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Journal ArticleDOI
Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3.
Natalia Sergina,Megan Rausch,Donghui Wang,Jimmy A. Blair,Byron Hann,Kevan M. Shokat,Mark M. Moasser +6 more
TL;DR: The experimental abrogation of HER3 resistance by small interfering RNA knockdown restores potent pro-apoptotic activity to otherwise cytostatic HER TKIs, re-affirming the oncogene-addicted nature of HER2-driven tumours and the therapeutic promise of this oncoprotein target.
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A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis
Maddalena Adorno,Michelangelo Cordenonsi,Marco Montagner,Sirio Dupont,Christine E. Wong,Byron Hann,Aldo Solari,Sara Bobisse,Maria Rondina,Vincenza Guzzardo,Anna Parenti,Antonio Rosato,Silvio Bicciato,Allan Balmain,Stefano Piccolo +14 more
TL;DR: Two common oncogenic lesions, mutant-p53 and Ras, selected in early neoplasms to promote growth and survival, also prefigure a cellular set-up with particular metastasis proclivity by TGFbeta-dependent inhibition of p63 function.
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Pharmacological brake-release of mRNA translation enhances cognitive memory
Carmela Sidrauski,Diego Acosta-Alvear,Arkady Khoutorsky,Punitha Vedantham,Brian R. Hearn,Han Li,Karine Gamache,Ciara M Gallagher,Kenny K. H. Ang,Christopher W. Wilson,Voytek Okreglak,Avi Ashkenazi,Byron Hann,Karim Nader,Michelle R. Arkin,Adam R. Renslo,Nahum Sonenberg,Peter Walter +17 more
TL;DR: A small molecule is identified, named ISRIB, that potently reverses the effects of eIF2α phosphorylation and promises to contribute to the understanding and treatment of cognitive disorders.
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A Central Role for RAF→MEK→ERK Signaling in the Genesis of Pancreatic Ductal Adenocarcinoma
Eric A. Collisson,Christy L. Trejo,Jillian M. Silva,Shenda Gu,James E. Korkola,Laura M. Heiser,Roch-Philippe Charles,Brian Rabinovich,Byron Hann,David Dankort,Paul T. Spellman,Wayne A. Phillips,Joe W. Gray,Martin McMahon +13 more
TL;DR: It is shown that expression of BRAF(V600E), but not PIK3CA(H1047R), in the mouse pancreas leads to pancreatic intraepithelial neoplasia (PanIN) lesions, and RAF→MEK→ERK signaling is central to the initiation and maintenance of PDA and to rational combination strategies in this disease.
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Targeted tumor cell internalization and imaging of multifunctional quantum dot-conjugated immunoliposomes in vitro and in vivo.
Kevin C. Weng,Charles O. Noble,Brigitte Papahadjopoulos-Sternberg,Fanqing F. Chen,Daryl C. Drummond,Dmitri B. Kirpotin,Donghui Wang,Yun Kit Hom,Byron Hann,John W. Park +9 more
TL;DR: The synthesis, biophysical characterization, tumor cell-selective internalization, and anticancer drug delivery of QD-conjugated immunoliposome-based nanoparticles (QD-ILs) are described to incorporate the unique optical properties of luminescent quantum dots into immunolIPosomes for cancer diagnosis and treatment.