Dilhan Weeraratne

TL;DR: Using the epitope information along with variants of the virus, it is found several variants which might cause drifts, including 23403A>G variant in spike protein B-cell epitope, which is observed frequently in European countries, such as the Netherlands, Switzerland, and France, but seldom observed in China.

TL;DR: Translational research exploring the convergence of artificial intelligence and precision medicine will help solve the most difficult challenges facing precision medicine, especially those in which nongenomic and genomic determinants, combined with information from patient symptoms, clinical history, and lifestyles, will facilitate personalized diagnosis and prognostication.

TL;DR: Using the epitope information along with variants of the virus, it is found several variants which might cause drifts, including 23403A>G variant in spike protein B-cell epitope, which is observed frequently in European countries, such as the Netherlands, Switzerland, and France, but seldom observed in China.

TL;DR: In this paper, the authors analyzed 30493 genomes sampled in Japan were analyzed to understand the strains, heterogeneity and temporal evolution of different SARS-CoV-2 strains and identified 12 discrete strains with a substantial number of cases with most strains possessing the spike (S) D614G and nucleocapsid (N) 203_204delinsKR mutations.

TL;DR: This review provides frontline clinicians with a pragmatic summary of the current state of the rapidly evolving evidence supporting emerging candidate therapeutics for COVID-19 and two main categories of pharmaceutical therapeutics are showing promise—those with antiviral activity directly addressing infection and those that counteract the inflammatory cytokine storm induced by severe disease.