Dimitrios Kapogiannis

TL;DR: Proteins pathogenic in Alzheimer's disease were extracted from neurally derived blood exosomes and quantified to develop biomarkers for the staging of sporadic AD.

TL;DR: Therapeutic interventions to allay cognitive dysfunction that target energy metabolism and adaptive stress responses (such as neurotrophin signalling) have been effective in animal models and in preliminary studies in humans.

TL;DR: Levels of autolysosomal proteins in neurally derived blood exosomes distinguish patients with AD from case controls and appear to reflect the pathology of AD up to 10 years before clinical onset.

TL;DR: The rising attention to EV‐resident RNAs as biomarkers stems from the fact that RNAs can be detected at extremely low quantities using a number of methods, and this work discusses EV RNAs in cancer and neurodegeneration, two major age‐associated disease processes.

TL;DR: Ex-4 ameliorated the diabetic effects of STZ in 3xTg-AD mice, elevating plasma insulin and lowering both plasma glucose and hemoglobin A1c (HbA1c) levels and brain levels of Abeta protein precursor and Abeta were significantly reduced in Ex-4 treated mice.