Ding Li

TL;DR: It is demonstrated that the G-quadruplex structure was disrupted when partial mutation of G --> A was made, resulting in a 2-fold increase in basal transcriptional activity of bcl-2 promoter, and G- quadruplex specific ligands could regulate the transcription of bCl-2 through stabilization of quadruplex structure.

TL;DR: The results showed that the effect of G-quadruplex ligand SYUIQ-05 on tumor cell lines and the mechanism of this effect showed that it preferred to bind with G- quadruplex in c-myc and had rather insignificant effect on G- quadruplex in telomere.

TL;DR: A novel single-chain variable fragment antibody, D1, with high binding selectivity for parallel G-quadruplexes in vitro and in vivo is reported, finding it to be a valuable tool for determination of G- quadruplex and its conformation.

TL;DR: A new series of tacrine-multialkoxybenzene hybrids (9a-9n) were designed, synthesized and evaluated as dual inhibitors of cholinesterases (ChEs) and self-induced β-amyloid aggregation and showed higher self- induced Aβ aggregation inhibitory activity than a reference compound, curcumin.

TL;DR: The reaction represents the first example of Cp*Ir(III)-catalysed C-H direct arylation reaction, and offers a facile, operationally simple and environmentally benign access to arylated phenols.