Zhi-Shu Huang

TL;DR: Molecular modeling studies revealed the binding mode between the derivatives and the G-quadruplexes is end-stacking at the 3'-position, and the positively charged side chain on the quindoline derivatives may contribute to the selectivity to certain loop isomers of topological quadruplexes as the improved stabilization action.

TL;DR: Kinetic study exhibited that the mechanism of alpha-glucosidase inhibition of both 3 and C(2) was non-competitive, and the structure activity relationship revealed that the ortho dihydroxyl groups could form a more tight interaction with alpha- glucosidease to exert more potential inhibitory activities.

TL;DR: Broad substrate scope, excellent functional group tolerance, and high yields were observed in the facile synthesis of carbazoles from readily available indoles using a tandem Cp*Rh(III)-Catalyzed C–H activation/Bronsted acid-catalyzed intramolecular cyclization.

TL;DR: A new red-emitting fluorescent probe, QUMA-1, is reported, for the selective, continuous, and real-time visualization of RNA G-quadruplexes in live cells, which revealed the complexity of the dynamics ofRNA G- quadruplexe inLive cells.

TL;DR: It is demonstrated that the G-quadruplex structure was disrupted when partial mutation of G --> A was made, resulting in a 2-fold increase in basal transcriptional activity of bcl-2 promoter, and G- quadruplex specific ligands could regulate the transcription of bCl-2 through stabilization of quadruplex structure.