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Yu-Jing Lu
Researcher at Guangdong University of Technology
Publications - 90
Citations - 2010
Yu-Jing Lu is an academic researcher from Guangdong University of Technology. The author has contributed to research in topics: Chemistry & Antibacterial activity. The author has an hindex of 18, co-authored 74 publications receiving 1496 citations. Previous affiliations of Yu-Jing Lu include Sun Yat-sen University & Hong Kong Polytechnic University.
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Journal ArticleDOI
Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc by quindoline derivatives
Tian-Miao Ou,Yu-Jing Lu,Chi Zhang,Zhi-Shu Huang,Xiao-Dong Wang,Jia-Heng Tan,Yuan Chen,Dik-Lung Ma,Kwok Yin Wong,Johnny Cheuk On Tang,Albert S. C. Chan,Lian-Quan Gu +11 more
TL;DR: Molecular modeling studies revealed the binding mode between the derivatives and the G-quadruplexes is end-stacking at the 3'-position, and the positively charged side chain on the quindoline derivatives may contribute to the selectivity to certain loop isomers of topological quadruplexes as the improved stabilization action.
Journal ArticleDOI
9-Substituted berberine derivatives as G-quadruplex stabilizing ligands in telomeric DNA
Wan-Jin Zhang,Tian-Miao Ou,Yu-Jing Lu,Ying-Yu Huang,Wei-Bin Wu,Zhi-Shu Huang,Jin-Lin Zhou,Kwok Yin Wong,Lian-Quan Gu +8 more
TL;DR: Introduction of a side chain with proper length of methylene and terminal amino group to the 9-position of berberine would significantly strengthen the binding affinity with G-quadruplex, resulting in increasing inhibitory effects on the amplification of telo21 DNA and on the telomerase activity.
Journal ArticleDOI
Turning off Transcription of the bcl-2 Gene by Stabilizing the bcl-2 Promoter Quadruplex with Quindoline Derivatives
Xiaodong Wang,Tian-Miao Ou,Yu-Jing Lu,Zeng Li,Zheng Xu,Chen Xi,Jia-Heng Tan,Shi-Liang Huang,Lin-Kun An,Ding Li,Lian-Quan Gu,Zhi-Shu Huang +11 more
TL;DR: It is demonstrated that the G-quadruplex structure was disrupted when partial mutation of G --> A was made, resulting in a 2-fold increase in basal transcriptional activity of bcl-2 promoter, and G- quadruplex specific ligands could regulate the transcription of bCl-2 through stabilization of quadruplex structure.
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9-N-Substituted berberine derivatives: Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc
TL;DR: The experiment results indicated that 9-N-substituted berberine derivatives could selectively induce and stabilize the formation of intramolecular parallel G-quadruplex in c- myc, which led to down-regulation of transcription of the c-myc in the HL60 lymphomas cell line.
Journal ArticleDOI
Inhibition of Cell Proliferation by Quindoline Derivative (SYUIQ-05) through its Preferential Interaction with c-myc Promoter G-Quadruplex
Tian-Miao Ou,Jing Lin,Yu-Jing Lu,Jin-Qiang Hou,Jia-Heng Tan,Shu-Han Chen,Zeng Li,Yan-Ping Li,Ding Li,Lian-Quan Gu,Zhi-Shu Huang +10 more
TL;DR: The results showed that the effect of G-quadruplex ligand SYUIQ-05 on tumor cell lines and the mechanism of this effect showed that it preferred to bind with G- quadruplex in c-myc and had rather insignificant effect on G- quadruplex in telomere.