Ding-Yah Yang

TL;DR: The results set the stage for further studies involving NTBC and its derivatives as new chemotherapeutic agents against PCM and confirm the potential of array-based approaches to identify new targets for the development of alternative treatments against pathogenic microorganisms.

TL;DR: The correlations between the results of enzyme inhibition, ferric chloride tests, and the conformational analysis suggested that the tight binding between triketone-type inhibitors and 4-HPPD is likely due to chelation of the enzyme-bound ferric iron with the enol tautomer of 1,3-diketone moiety of the triketones.

TL;DR: Two novel diphenacoum-derived analogues 5 and 6 are designed, synthesized and tested as potential vitamin K 2,3-epoxide reductase (VKOR) inhibitors, and it is indicated that 5 is a potent VKOR inhibitor, which confirmed that the replacement of the tetrahydronaphthalene on diphenACoum to a chroman functionality does not have a major impact on inhibition potency.

TL;DR: The efficient construction of a coumarin-pyrrole-isoquinoline-fused pentacycle via the visible-light-promoted cyclization of 4-(isoquinolin-1-ylmethyl)-3-nitrocoumarin or Yb(OTf)3-catalyzed coupling of 4-chloro-3-Nitrocou marin and 1-methylisoquin Caroline is reported.

TL;DR: A microwave-promoted, metal- and catalyst-free decarboxylative α,β-difunctionlization of secondary α-amino acids via a pseudo-four-component coupling of proline, aldehyde, and 1,3-diketone to generate multifunctionalized pyrano[2, 3-b]pyrrole and pyrrolizinone derivatives is reported.