Dipti Mangal

TL;DR: Oncogene-directed increased expression of Nrf2 is a new mechanism for the activation of the NRF2 antioxidant program, and is evident in primary cells and tissues of mice expressing K-RasG12D and B-RafV619E, and in human pancreatic cancer.

TL;DR: At low levels of oxidative DNA damage, there was an excellent correlation between a comet assay that measured DNA single strand breaks (SSBs) after treatment with human 8-oxo-guanine glycosylase-1 (hOGG1) when compared with 8-xo-dGuo in the DNA as measured by the stable isotope dilution LC-MRM/MS method.

TL;DR: It is concluded that activation of PAH-trans-dihydrodiols by AKRs in lung cells leads to ROS-mediated genotoxicity and contributes to lung carcinogenesis.

TL;DR: This study shows that the P4501A1/1B1 and AKR pathways are inducible in human lung cells and that the peroxidase pathway was not, and provides evidence that each of the pathways of PAH activation yields their distinctive metabolites in H358 human lung Cells and that each pathway may contribute to the carcinogenic process.

TL;DR: It is concluded that the AhR shuttles PAH o-quinone genotoxins to the nucleus and enhances oxidative DNA damage.