K
Kristopher K. Frese
Researcher at University of Manchester
Publications - 47
Citations - 9382
Kristopher K. Frese is an academic researcher from University of Manchester. The author has contributed to research in topics: Pancreatic cancer & Cancer. The author has an hindex of 26, co-authored 42 publications receiving 7984 citations. Previous affiliations of Kristopher K. Frese include Princess Margaret Cancer Centre & University College London.
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Journal ArticleDOI
Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
Kenneth P. Olive,Michael A. Jacobetz,Christian Davidson,Aarthi Gopinathan,Aarthi Gopinathan,Dominick J.O. McIntyre,Davina J. Honess,Basetti Madhu,Mae A. Goldgraben,Meredith E. Caldwell,David Allard,Kristopher K. Frese,Gina M. DeNicola,Gina M. DeNicola,Christine Feig,Chelsea Combs,Stephen P. Winter,Heather Ireland-Zecchini,Stefanie Reichelt,William J. Howat,Alex R. Chang,Mousumi Dhara,Lifu Wang,Lifu Wang,Felix Rückert,Robert Grützmann,Christian Pilarsky,Kamel Izeradjene,Sunil R. Hingorani,Pearl S. Huang,Susan E. Davies,William Plunkett,Merrill J. Egorin,Ralph H. Hruban,Nigel Whitebread,Karen McGovern,Julian Adams,Christine A. Iacobuzio-Donahue,John R. Griffiths,David A. Tuveson +39 more
TL;DR: Studying a mouse model of PDA that is refractory to the clinically used drug gemcitabine, it is found that the tumors in this model were poorly perfused and poorly vascularized, properties that are shared with human PDA.
Journal ArticleDOI
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
Gina M. DeNicola,Florian A. Karreth,Timothy J. Humpton,Aarthi Gopinathan,Cong Wei,Kristopher K. Frese,Dipti Mangal,Kenneth H. Yu,Charles J. Yeo,Eric S. Calhoun,Francesca Scrimieri,Jordan M. Winter,Ralph H. Hruban,Christine A. Iacobuzio-Donahue,Scott E. Kern,Ian A. Blair,David A. Tuveson +16 more
TL;DR: Oncogene-directed increased expression of Nrf2 is a new mechanism for the activation of the NRF2 antioxidant program, and is evident in primary cells and tissues of mice expressing K-RasG12D and B-RafV619E, and in human pancreatic cancer.
Journal ArticleDOI
Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer
Michael A. Jacobetz,Derek S. Chan,Albrecht Neesse,Tashinga E. Bapiro,Natalie Cook,Kristopher K. Frese,Christine Feig,Tomoaki Nakagawa,Meredith E. Caldwell,Heather I Zecchini,Martijn P. Lolkema,Ping Jiang,Anne Kultti,Curtis B. Thompson,Daniel C. Maneval,Duncan I. Jodrell,Gregory I. Frost,Harold Michael Shepard,Jeremy N. Skepper,David A. Tuveson +19 more
TL;DR: It is demonstrated that HA impedes the intratumoral vasculature in PDA and proposed that its enzymatic depletion be explored as a means to improve drug delivery and response in patients with pancreatic cancer.
Journal ArticleDOI
Maximizing mouse cancer models
TL;DR: It is only now that scientists are realising the full potential of mouse models of cancer and what new approaches are needed to derive the maximum value for cancer patients from this investment.
Journal ArticleDOI
Stromal biology and therapy in pancreatic cancer
Albrecht Neesse,Patrick Michl,Kristopher K. Frese,Christine Feig,Natalie Cook,Mike A Jacobetz,Martijn P. Lolkema,Malte Buchholz,Kenneth P. Olive,Thomas M. Gress,David A. Tuveson +10 more
TL;DR: Stromal cells contained within the PDA tumour microenvironment represent an additional constituent to neoplastic cells that should be critically evaluated for optimal therapeutic development in preclinical models and early clinical trials.