D
Dirk Weisensee
Publications - 11
Citations - 334
Dirk Weisensee is an academic researcher. The author has contributed to research in topics: Systems biology & In vivo. The author has an hindex of 6, co-authored 11 publications receiving 313 citations.
Papers
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Journal ArticleDOI
Human bronchial epithelial cells exposed in vitro to cigarette smoke at the air-liquid interface resemble bronchial epithelium from human smokers
Carole Mathis,Carine Poussin,Dirk Weisensee,Stephan Gebel,Arnd Hengstermann,Alain Sewer,Vincenzo Belcastro,Yang Xiang,Sam Ansari,Sandra Wagner,Julia Hoeng,Manuel C. Peitsch +11 more
TL;DR: A similar biological perturbation than the one observed in vivo in smokers' airway epithelium could be induced after a single CS exposure of a human organotypic bronchial epithelia-like tissue culture.
Journal ArticleDOI
Assessment of network perturbation amplitudes by applying high-throughput data to causal biological networks
Florian Martin,Ty M. Thomson,Alain Sewer,David A. Drubin,Carole Mathis,Dirk Weisensee,Dexter Pratt,Julia Hoeng,Manuel C. Peitsch +8 more
TL;DR: The NPA scoring method leverages high-throughput measurements and a priori literature-derived knowledge in the form of network models to characterize the activity change for a broad collection of biological processes at high-resolution.
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A Modular Cell-Type Focused Inflammatory Process Network Model for Non-Diseased Pulmonary Tissue
Jurjen W. Westra,Walter K. Schlage,Arnd Hengstermann,Stephan Gebel,Carole Mathis,Ty M. Thomson,Ben Wong,Vy Hoang,Emilija Veljkovic,Michael Peck,Rosemarie B. Lichtner,Dirk Weisensee,Marja Talikka,Renée Deehan,Julia Hoeng,Manuel C. Peitsch +15 more
TL;DR: The IPN provides a comprehensive framework of experimentally supported pathways related to CS-induced pulmonary inflammation and predicted decreased epithelial cell barrier defenses and increased mucus hypersecretion in human bronchial epithelial cells, and an attenuated pro-inflammatory profile in alveolar macrophages following exposure to CS.
Journal ArticleDOI
A Systems Biology Approach Reveals the Dose- and Time-Dependent Effect of Primary Human Airway Epithelium Tissue Culture After Exposure to Cigarette Smoke In Vitro
Carole Mathis,Stephan Gebel,Carine Poussin,Vincenzo Belcastro,Alain Sewer,Dirk Weisensee,Arnd Hengstermann,Sam Ansari,Sandra Wagner,Manuel C. Peitsch,Julia Hoeng +10 more
TL;DR: An in vitro systems toxicology approach has potential for product testing according to “21st Century Toxicology” and a follow-up evaluation of in vitro transcriptomics data is presented, using complementary computational approaches and an integrated mRNA-microRNA (miRNA) analysis.
Journal ArticleDOI
Cigarette smoke-induced morphological transformation of Bhas 42 cells in vitro.
TL;DR: This in vitro assay with Bhas 42 cells is able to detect cell transformation induced by cigarette smoke in a dose-dependent manner with a high sensitivity and good precision and may be useful in product assessment, as well as for further investigation of the non-geno-toxic carcinogenic activity of tobacco smoke-related test substances.