A
Arnd Hengstermann
Publications - 14
Citations - 667
Arnd Hengstermann is an academic researcher. The author has contributed to research in topics: Systems biology & Enhancer. The author has an hindex of 10, co-authored 14 publications receiving 634 citations.
Papers
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Journal ArticleDOI
Human bronchial epithelial cells exposed in vitro to cigarette smoke at the air-liquid interface resemble bronchial epithelium from human smokers
Carole Mathis,Carine Poussin,Dirk Weisensee,Stephan Gebel,Arnd Hengstermann,Alain Sewer,Vincenzo Belcastro,Yang Xiang,Sam Ansari,Sandra Wagner,Julia Hoeng,Manuel C. Peitsch +11 more
TL;DR: A similar biological perturbation than the one observed in vivo in smokers' airway epithelium could be induced after a single CS exposure of a human organotypic bronchial epithelia-like tissue culture.
Journal ArticleDOI
A computable cellular stress network model for non-diseased pulmonary and cardiovascular tissue
Walter K. Schlage,Jurjen W. Westra,Stephan Gebel,Natalie L. Catlett,Carole Mathis,Brian P. Frushour,Arnd Hengstermann,Aaron A. Van Hooser,Carine Poussin,Ben Wong,Michael Lietz,Jennifer Park,David A. Drubin,Emilija Veljkovic,Manuel C. Peitsch,Julia Hoeng,Renée Deehan +16 more
TL;DR: The construction of a cellular stress network model and its application towards the analysis of environmental stress using transcriptomic data is described and the ability of the network model to identify the mechanisms that are activated in response to CS, a broad inducer of cellular stress is tested.
Journal ArticleDOI
Endoplasmic reticulum stress induced by aqueous extracts of cigarette smoke in 3T3 cells activates the unfolded-protein-response-dependent PERK pathway of cell survival
Arnd Hengstermann,Thomas Müller +1 more
TL;DR: Data is presented indicating that noncytotoxic concentrations of aqueous extracts of CS induce a distinct ER stress response in immortalized nontransformed Swiss 3T3 cells, primarily by activating the PERK pathway of global protein synthesis inhibition.
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Construction of a computable cell proliferation network focused on non-diseased lung cells
Jurjen W. Westra,Walter K. Schlage,Brian P. Frushour,Stephan Gebel,Natalie L. Catlett,Wanjiang Han,Sean Eddy,Arnd Hengstermann,Andrea L. Matthews,Carole Mathis,Rosemarie B. Lichtner,Carine Poussin,Marja Talikka,Emilija Veljkovic,Aaron A. Van Hooser,Benjamin Wong,Michael J. Maria,Manuel C. Peitsch,Renée Deehan,Julia Hoeng +19 more
TL;DR: A lung-focused Cell Proliferation Network is constructed, which is believed to be the most comprehensive connectivity map in existence of the molecular mechanisms regulating cell proliferation in the lung.
Journal ArticleDOI
Nrf2: friend and foe in preventing cigarette smoking-dependent lung disease.
Thomas Müller,Arnd Hengstermann +1 more
TL;DR: The intention of this review is to compile and discuss the various aspects of CS-Nrf2/Keap1 interaction in terms of mechanism, disease development, and chemoprevention.