Julia Hoeng

TL;DR: Systems Toxicology approaches offer modern strategies for gaining mechanistic knowledge by combining advanced analytical and computational tools, and integrates current knowledge regarding bioanalytical approaches, computational analysis, and the potential for improved risk assessment.

TL;DR: GenSA as discussed by the authors is a package for generalized simulated annealing to process complicated nonlinear objective functions with a large number of local minima, which can serve as a complementary tool to other widely used R packages for optimization.

TL;DR: A brief introduction to the GenSA R package is provided and its utility is demonstrated by solving a non-convex portfolio optimization problem in finance and the Thomson problem in physics.

TL;DR: The clinical study confirmed the reduced exposure to HPHCs in smokers switching to THS2.2, and the associated transcriptomic study confirmedThe utility of a gene expression signature, consisting of only 11 genes tested in the blood transcriptome of subjects enrolled in the clinical study, as a complementary measure of exposure response.

TL;DR: It is found that the level of qualification of MPS-based assays for a given context of use and communication gaps between stakeholders are the major challenges slowing industrial adoption by end users, which in turn is causing a regulatory acceptance dilemma.